snOPY: a small nucleolar RNA orthological gene database.
snOPY: a small nucleolar RNA orthological gene database.
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DOI：
10.1186/1756-0500-6-426
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发表时间：
2013-10-23
影响因子：
1.8
通讯作者：
Kenmochi N
中科院分区：
文献类型：
--
作者：
Yoshihama M;Nakao A;Kenmochi N
小核仁rna （Small nucleolar rna, snoRNAs）是一类指导核糖体rna （RNAs）和小核rna （snrna）中特定核苷酸修饰的非编码rna。尽管大多数非编码rna在成熟前经历转录后修饰，但这些修饰的功能意义尚不清楚。在这里，我们介绍了snoRNA同源基因数据库（snOPY）作为研究RNA修饰的工具。snOPY提供了有关snoRNA、snoRNA基因位点和目标rna的全面信息。它还包含来自不同物种的同源物数据，使用户能够分析snoRNA基因的进化。共登记到snoRNA基因13770个，snoRNA基因位点10345个，靶rna 133个。用户可以使用带有一系列内部链接的简单web界面高效地搜索和访问数据。snOPY可以在http://snoopy.med.miyazaki-u.ac.jp上免费获得。snOPY是一个提供小核仁rna及其同源物信息的数据库。它将帮助用户研究RNA修饰和snoRNA基因进化。
Small nucleolar RNAs (snoRNAs) are a class of non-coding RNAs that guide the modification of specific nucleotides in ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs). Although most non-coding RNAs undergo post-transcriptional modifications prior to maturation, the functional significance of these modifications remains unknown. Here, we introduce the snoRNA orthological gene database (snOPY) as a tool for studying RNA modifications. snOPY provides comprehensive information about snoRNAs, snoRNA gene loci, and target RNAs. It also contains data for orthologues from various species, which enables users to analyze the evolution of snoRNA genes. In total, 13,770 snoRNA genes, 10,345 snoRNA gene loci, and 133 target RNAs have been registered. Users can search and access the data efficiently using a simple web interface with a series of internal links. snOPY is freely available on the web at http://snoopy.med.miyazaki-u.ac.jp. snOPY is the database that provides information about the small nucleolar RNAs and their orthologues. It will help users to study RNA modifications and snoRNA gene evolution.