Identification of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/07_BC) in Men Who Have Sex with Men in Beijing, China
Identification of a Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/07_BC) in Men Who Have Sex with Men in Beijing, China
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DOI：
10.1089/aid.2018.0228
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发表时间：
2019-05-01
影响因子：
1.5
通讯作者：
Lu, Hongyan
中科院分区：
文献类型：
--
作者：
Hao, Mingqiang;Wang, Juan;Lu, Hongyan
HIV-1 CRF01_AE和CRF07_BC是北京地区男男性接触者（MSM）中流行的两个主要HIV-1毒株。这两种亚型占2016年北京新诊断的HIV-1阳性病例的78.1%。在本研究中，我们报告了一个新的CRF01_AE/CRF07_BC第二代独特的重组形式（URF）（命名为DT1427_NFLG）的HIV-1在MSM人群中发现。DT1427_NFLG的近全长基因组约为8.8 kb，其中4个CRF07_BC片段插入CRF01_AE骨架中。在我国，近年来出现了多个新的第二代URF，北京作为我国首都，吸引了全国各地大量的人口来此工作和生活，面临着重组HIV-1毒株流行的风险。因此，有必要对HIV-1新重组体的出现进行监测。
HIV-1 CRF01_AE and CRF07_BC have been two mainly circulating HIV-1 strains in the men who have sex with men (MSM) population in Beijing for years. These two subtypes together were accounting for 78.1% of HIV-1 positive cases newly diagnosed in Beijing, 2016. In this study, we report a novel CRF01_AE/CRF07_BC second-generation unique recombinant form (URF) (named DT1427_NFLG) of HIV-1 identified in MSM population. The near full-length genome of DT1427_NFLG is about 8.8 kb with four CRF07_BC fragments inserted into the CRF01_AE backbone. In China, several novel second-generation URFs were reported in recent years and Beijing, as the capital of China, attracting a huge number of people all over the country to work and live, is confronted with the risk of the epidemic of recombinant HIV-1 strains. Therefore, it is necessary to take measures to monitor the emergency of novel recombinant of HIV-1.