Supplemented nutrition increases immunity and drug efficacy in a natural host-helminth system
Supplemented nutrition increases immunity and drug efficacy in a natural host-helminth system
复制标题
补充营养可提高天然宿主-蠕虫系统的免疫力和药物功效
DOI：
10.1101/837617
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
A. B. Pedersen
中科院分区：
文献类型：
--
作者：
A. Sweeny;Melanie Clerc;Paulina A. Pontifes;Saudamini Venkatesan;S. Babayan;A. B. Pedersen
Gastrointestinal helminths are common parasites of humans, wildlife, and livestock, leading to chronic infections in large parts of the world. In humans, there is also an overlap in the incidence of malnutrition and helminth infections which can predispose individuals to higher infection burdens and reduced anthelmintic efficacy due to compromised immunity. This relationship has been well-studied in laboratory models by testing for the impact of dramatic reductions of specific nutrients on infection outcomes. However, much less is known about the benefits of whole-diet supplementation in natural host-helminth systems. We experimentally supplemented the diet of wood mice (Apodemus sylvaticus) and measured resistance to the gastrointestinal nematode Heligmosomoides polygyrus and anthelmintic treatment efficacy in both natural and captive populations. Supplemented wood mice were more resistant to H. polygyrus infection, cleared worms more efficiently after treatment, produced stronger general and parasite-specific antibody responses, and maintained better body condition. In addition, supplemented nutrition in conjunction with anthelminthic treatment significantly reduced H. polygyrus transmission potential. These large-scale improvements in condition and immunity of supplemented nutrition found in controlled and wild environments show the rapid and extensive benefits of a well-balanced diet and have important implications for using diet interventions to improve disease control programmes.
DOI：
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发表时间：
1999-06
期刊：
Laboratory animal science
影响因子：
--
作者：
Mollie Ullman-Cullere;C. Foltz
通讯作者：
Mollie Ullman-Cullere;C. Foltz