Colonoscopy screening in African Americans and whites with affected first-degree relatives
Colonoscopy screening in African Americans and whites with affected first-degree relatives
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DOI：
10.1001/archinte.168.6.625
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发表时间：
2008-03-24
影响因子：
--
通讯作者：
Blot, William J.
中科院分区：
文献类型：
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作者：
Murff, Harvey J.;Peterson, Neeraja B.;Blot, William J.
背景：家族史是结肠癌的危险因素，指南建议在 40 岁时开始对有患病亲属的个体进行筛查。结肠癌死亡率的种族差异可能与高风险个体筛查的差异有关。方法：对南方社区队列研究中 41830 名参与者的基线数据进行分析，以确定有强烈结肠癌家族史的个体中接受结肠镜检查的比例，以及是否存在基于种族的差异。结果：在有多个受影响的一级亲属 (FDR) 或 50 岁之前诊断的亲属的参与者中，27.3%（95% 置信区间 [CI]， 23.5%31.1%）的非裔美国人报告在过去 5 年内接受过结肠镜检查，而白人参与者的这一比例为 43.1%（95% CI，37.0%-49.2%）（P
Background: Family history is a risk factor for colon cancer, and guidelines recommend initiating screening at age 40 years in individuals with affected relatives. Racial differences in colon cancer mortality could be related to variations in screening of increased-risk individuals.Methods: Baseline data from 41830 participants in the Southern Community Cohort Study were analyzed to determine the proportion of colonoscopy procedures in individuals with strong family histories of colon cancer, and whether differences existed based on race.Results: In participants with multiple affected first-degree relatives (FDRs) or relatives diagnosed before age 50 years, 27.3% (95% confidence interval [CI], 23.5%31.1%) of African Americans reported having a colonoscopy within the past 5 years compared with 43.1% (95% CI, 37.0%-49.2%) of white participants (P