Characteristics of Framingham offspring participants with long-lived parents
Characteristics of Framingham offspring participants with long-lived parents
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DOI：
10.1001/archinte.167.5.438
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发表时间：
2007-03-12
影响因子：
--
通讯作者：
Benjamin, Emelia J.
中科院分区：
文献类型：
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作者：
Terry, Dellara F.;Evans, Jane C.;Benjamin, Emelia J.
背景：先前的研究表明，延迟或避免心血管疾病和心血管疾病危险因素在长寿中起着重要作用。方法：我们研究了1697例30岁及以上的Framingham Heart Study （FHS）后代成员，他们的父母(1)参加了最初的FHS队列，(2)年龄达到85岁或在2005年1月1日前去世。后代参与者（平均+/-年龄，40 +/- 7岁，51%为女性）根据父母双方（n= 188）是否存活至85岁或以上进行分组。我们在检查周期1（1971-1975）检查了后代的危险因素，包括年龄、性别、教育程度、吸烟、收缩压和舒张压、总高密度脂蛋白胆固醇比、体重指数和Framingham风险评分。在检查周期3 （1983-1987;n= 1319）返回的参与者有资格纳入纵向分析，评估从基线到更高随访风险类别的风险因素进展。结果：在所有研究因素中，除了体重指数外，我们观察到随着父母生存类别的增加，后代检查1风险因素水平降低具有统计学意义的线性趋势。平均弗雷明汉风险评分在父母双方都活到85岁或以上的后代中最有利，而在父母一方或一方不长寿的后代中逐渐变差(分别为0.55,1.08和1.71；趋势P值；
Background: Prior research has suggested that delay or avoidance of cardiovascular disease and cardiovascular disease risk factors plays an important role in longevity.Methods: We studied 1697 Framingham Heart Study (FHS) offspring members 30 years or older, whose parents (1) participated in the original FHS cohort and (2) achieved age 85 years or died before January 1, 2005. Offspring participants (mean +/- SDage, 40 +/- 7 years; 51% women) were grouped according to whether neither (n= 705), one (n= 804), or both parents ( n= 188) survived to 85 years or older. We examined offspring risk factors at examination cycle 1 (1971-1975) including age, sex, education, cigarette smoking, systolic and diastolic blood pressures, total-high-density lipoprotein cholesterol ratio, body mass index, and Framingham Risk Score. Participants returning for examination cycle 3 (1983-1987; n= 1319) were eligible for inclusion in longitudinal analyses evaluating risk factor progression from baseline to a higher follow-up risk category.Results: For all factors studied, except body mass index, we observed statistically significant linear trends for lower offspring examination 1 risk factor levels with increasing parental survival category. The mean Framingham Risk Score was most favorable in offspring with both parents surviving to 85 years or older and was progressively worse in those with one or no long-lived parent (0.55, 1.08, and 1.71, respectively; P value for trend,