HIV Susceptibility of human antigen-specific CD4 T cells in AIDS pathogenesis and vaccine response.
HIV Susceptibility of human antigen-specific CD4 T cells in AIDS pathogenesis and vaccine response.
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DOI：
10.1586/14760584.2016.1147354
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发表时间：
2016-06
影响因子：
6.2
通讯作者：
Ratto-Kim S
中科院分区：
文献类型：
--
作者：
Hu H;Liu F;Kim J;Ratto-Kim S
HIV引起感染并逐渐消耗人类CD4 T细胞。新出现的数据表明，抗原特异性CD4 t细胞亚群对HIV表现出不同的易感性，可能导致病原体特异性免疫失败和机会性感染。这一概念最近在艾滋病毒疫苗试验中使用的载体的背景下进行了探讨，数据表明，由Ad5-HIV疫苗引发的腺病毒5型（Ad5）特异性CD4 T细胞可能特别容易感染艾滋病毒，可能使Ad5疫苗接种者容易感染艾滋病毒。我们在此研究了在感染或HIV疫苗接种期间诱导的抗原特异性CD4 T细胞的HIV易感性的最新数据，并讨论了其对HIV疫苗接种引起的HIV感染风险的潜在影响。
HIV causes infection and progressive depletion of human CD4 T cells. Emerging data have shown that antigen-specific CD4 T-cell subsets manifest differential susceptibility to HIV, potentially leading to pathogen-specific immune failure and opportunistic infections. This concept was recently explored in context of vectors utilized in HIV vaccine trials, and the data suggest that adenovirus type 5(Ad5)-specific CD4 T cells elicited by Ad5-HIV vaccine may be particularly susceptible to HIV, potentially rendering Ad5 vaccine recipients susceptible to HIV acquisition. We here examined recent data regarding the HIV susceptibility of antigen-specific CD4 T cells induced during infection or HIV vaccination and discussed its potential impact on HIV acquisition risk posed by HIV vaccination.