Kinetic modeling of hormone release: application to time-averaged met-enkephalin release.
Kinetic modeling of hormone release: application to time-averaged met-enkephalin release.
复制标题
激素释放的动力学模型：应用于时间平均甲硫氨酸脑啡肽释放。
DOI：
10.1016/0306-4530(87)90066-7
复制
发表时间：
1987
影响因子：
3.7
通讯作者：
Quock,RM
中科院分区：
文献类型：
--
作者：
Swartz,CM;Quock,RM
响应于刺激的激素浓度的时间过程可以用动力学方法表征，以表示激素释放和消除的速率、激素释放的总量和预期的最佳采血时间。常规应用动力学方法应增加激素激发试验的敏感性和适用性。TRH测试和催乳素释放测量的应用程序进行审查。一个新的动力学模型，连续收集样品应用于测量甲硫氨酸脑啡肽释放大鼠。计算表明初始浓度为1876 pg/ml，心室分布容积为0.25 ml。在大鼠暴露于一氧化二氮后，向心室释放甲硫氨酸脑啡肽样活性的速率从3.4 pg/min上升到8.3 pg/min。
The time course of hormone concentrations in response to a stimulus can be characterizied with kinetic methods to express rates of hormone release and elimination, total amount of hormone release and expected best times for blood sampling. Routine application of kinetic methods should increase the sensitivity and applicability of hormonal challenge tests. Applications to the TRH test and to prolactin release measurements are reviewed. A new kinetic model for continuously collected samples is applied to measurements of met-enkephalin release in rats. Calculations indicated an initial concentration of 1876 pg/ml and a ventricular volume of distribution of 0.25 ml. After exposure of rats to nitrous oxide, the rate of release of met-enkephalin-like activity into the ventricles rose from 3.4 to 8.3 pg/min.