Potent suppressive effects of urocortin on splenic lymphocyte activity in rats
Potent suppressive effects of urocortin on splenic lymphocyte activity in rats
复制标题
尿皮质素对大鼠脾淋巴细胞活性的有效抑制作用
作者：
S. Okamoto;I. Ishikawa;Kazuhiro Kimura;M. Saito
为探讨新近发现的促肾上腺皮质激素释放因子(CRF)相关神经肽urocortin在外周免疫功能调节中的可能作用，本实验观察了大鼠脑内注射urocortin对脾淋巴细胞增殖活性的影响。脑室内(i.c.v.)注射Urocortin(1 Ng)可显著降低脾细胞对有丝分裂原的增殖反应。预先给予神经节阻滞剂(氯异丹明)或β-肾上腺素能受体拮抗剂(心得安)可取消Urocortin的抑制作用，但不能被肾上腺切除所阻断。这些结果表明，urocortin是一种重要的神经肽，参与大脑对应激诱导的免疫抑制等外周免疫功能的控制，并且urocortin的抑制作用是由交感神经系统介导的。
To assess the possible role of urocortin, a recently identified neuropeptide related to corticotropin-releasing factor (CRF), in modulation of peripheral immune functions, the effects of intracranially administrated urocortin on the proliferative activity of splenic lymphocytes were examined in rats. Intracerebroventricular (i.c.v.) injection of urocortin (1 ng) produced a marked decrease in the proliferative response of splenocytes to a mitogen. The suppressive effect of urocortin was abolished by pretreatment with a ganglionic blocking agent (chlorisondamine) or β-adrenergic receptor antagonist (propranolol), but not by adrenalectomy. These results suggest that urocortin is an important neuropeptide involved in the brain control of peripheral immune functions such as stress-induced immunosuppression, and that the suppressive effect of urocortin is mediated by the sympathetic nervous system.