Decreased brain serotonin transporter binding in the euthymic state of bipolar I but not bipolar II disorder: a SPECT study
Decreased brain serotonin transporter binding in the euthymic state of bipolar I but not bipolar II disorder: a SPECT study
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DOI：
10.1111/j.1399-5618.2010.00800.x
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发表时间：
2010-05-01
影响因子：
5.4
通讯作者：
Liao, Mei-Hsiu
中科院分区：
文献类型：
--
作者：
Chou, Yuan-Hwa;Wang, Shyh-Jen;Liao, Mei-Hsiu
目的：以往的正电子发射断层扫描研究表明，双相情感障碍(BD)抑郁状态下中脑5-羟色胺转运体(SERT)结合减少。本研究的目的是评估BD患者中脑中SERT的结合情况。方法：选择28例健康对照和24例药物BD患者。乐观状态定义为连续8周内的蒙哥马利-阿斯伯格抑郁量表评分10分和青年躁狂评定量表评分7分。用放射性示踪剂123I-ADAM单光子发射计算机断层扫描测量中脑SERT结合。数据分析采用平衡比率模型。结果：正常对照组和BD患者的SERT平均摄取率差异无统计学意义(p=0.27)。然而，对不同教育年限和性别的健康对照组、双相障碍(BD I)和双相II障碍(BD II)患者的SURS进行三因素方差分析发现，BD I患者的SURS平均值显著低于BD II患者和健康对照组(P=0.042)。BD I和BD II患者SURS的降低仅与病程相关(R=-0.742，P=0.014)。结论：BD I和BD II患者在稳定治疗后存在不同的生物学调节，这可能支持BD存在二分法。
Objectives:Previous positron emission tomography studies have demonstrated that serotonin transporter (SERT) binding in the midbrain is decreased in the depressive state of bipolar disorder (BD). The aim of this study was to assess SERT binding in the midbrain of patients in a euthymic state of BD.Methods:Twenty-eight healthy controls and 24 patients in a euthymic state of medicated BD were recruited. Euthymic state was defined as Montgomery-Asberg Depression Rating Scale scores < 10 and Young Mania Rating Scale scores < 7 within a consecutive eight-week period. Single photon emission computed tomography with the radiotracer 123I-ADAM was used to measure SERT binding in the midbrain. An equilibrium ratio model was used for data analysis. Specific uptake ratio (SUR), which represents availability of SERT binding in the midbrain, was the primary measurement outcome.Results:The averaged SURs were not different between healthy controls and BD patients in euthymic state (p = 0.27). However, a three-way ANCOVA analysis comparing SURs in healthy controls, bipolar I disorder (BD I) patients, and bipolar II disorder (BD II) patients, covarying education duration and sex, showed that the averaged SURs were significantly lower in BD I than BD II patients and healthy controls (p = 0.042). The decreased SURs in BD I patients were well correlated with duration of illness (R = -0.742, p = 0.014) only.Conclusions:Our findings demonstrate that there is differential biological regulation in BD I and BD II patients after stable treatment, which may support the existence of a dichotomy in BD.