Current Understanding of Pathological Mechanisms of Lymphedema.
Current Understanding of Pathological Mechanisms of Lymphedema.
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目前对淋巴水肿病理机制的认识。
DOI：
10.1089/wound.2021.0041
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发表时间：
2022
影响因子：
4.9
通讯作者：
Wong,AlexK
中科院分区：
文献类型：
--
作者：
Sung,Cynthia;Wang,Sarah;Hsu,Jerry;Yu,Roy;Wong,AlexK
意义：淋巴水肿是一种常见疾病，影响着全球数亿人，给人们带来巨大的经济和社会负担。尽管淋巴水肿的发病率和相关发病率不断增加，但由于对疾病的不完全了解，主要的治疗方法是姑息性的，没有有效的治疗方法。最新进展：最近的研究描述了导致淋巴水肿进展的关键组织学和病理学过程，包括淋巴滞留、炎症、脂肪组织沉积和纤维化。这篇综述旨在强调这些病理过程中涉及的细胞和分子机制。关键问题：尽管最近在淋巴水肿的病理生理学方面取得了进展，但由于其复杂的性质，其潜在的细胞和分子机制仍然难以捉摸。未来的方向：需要更多的研究来更好地了解淋巴水肿的病理生理学机制，这将指导针对疾病特定病理的治疗策略的发展。
Significance:Lymphedema is a common disease that affects hundreds of millions of people worldwide with significant financial and social burdens. Despite increasing prevalence and associated morbidities, the mainstay treatment of lymphedema is largely palliative without an effective cure due to incomplete understanding of the disease.Recent Advances:Recent studies have described key histological and pathological processes that contribute to the progression of lymphedema, including lymphatic stasis, inflammation, adipose tissue deposition, and fibrosis. This review aims to highlight cellular and molecular mechanisms involved in each of these pathological processes.Critical Issues:Despite recent advances in the understanding of the pathophysiology of lymphedema, cellular and molecular mechanisms underlying the disease remains elusive due to its complex nature.Future Directions:Additional research is needed to gain a better insight into the cellular and molecular mechanisms underlying the pathophysiology of lymphedema, which will guide the development of therapeutic strategies that target specific pathology of the disease.