Chemical components from the leaves of Ardisia insularis and their cytotoxic activity
Chemical components from the leaves of Ardisia insularis and their cytotoxic activity
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DOI：
10.1007/s12272-015-0591-x
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发表时间：
2015-03
影响因子：
6.7
通讯作者：
Nguyen Thi Hong Van;Trinh Anh Vien;P. Kiem;C. Minh;N. X. Nhiem;P. Long;Lưu Tuấn Anh;Nanyoung Kim;S. Park;S. Kim
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文献类型：
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作者：
Nguyen Thi Hong Van;Trinh Anh Vien;P. Kiem;C. Minh;N. X. Nhiem;P. Long;Lưu Tuấn Anh;Nanyoung Kim;S. Park;S. Kim
分离得到1个新齐墩果烷三萜苷(1)和12个已知化合物，分别为去甲氧基岩白菜素(2)、去甲基岩白菜素(3)、岩白菜素(4)、4-O-没食子酸岩白菜素(5)、槲皮苷(6)、杨梅苷(7)、杨梅素3-O-(3‘-O-没食子酸)-α-L-鼠李糖苷(8)、地甘氨酸-2(9)、表儿茶素3-O-没食子酸酯(10)、3’-甲氧基儿茶素3-O-没食子酸酯(11)、没食子酸(12)和没食子酸甲酯(13)。它们的结构是根据光谱和化学证据确定的，与文献报道的结果一致。这些化合物对A-549(人肺癌)、HT-29(人结肠腺癌)和OVCAR(人卵巢癌)三种癌细胞株的细胞毒活性进行了评价。结果表明，化合物1对A-549、HT-29和OVCAR细胞的IC50值分别为8.5±11.2、16.4±33.1和13.6±0.24μM。其余化合物表现出较弱的细胞毒活性。这一结果表明化合物1可用于癌症的治疗。
One new oleanane triterpene glycoside, ardinsuloside (1), and twelve known compounds, demethoxybergenin (2), norbergenin (3), bergenin (4), 4-O-galloylbergenin (5), quercitrin (6), myricitrin (7), myricetin 3-O-(3′′-O-galloyl)-α-l-rhamnopyranoside (8), desmanthine-2 (9), epicatechin 3-O-galloyl ester (10), 3′-methoxyepicatechin 3-O-galloyl ester (11), gallic acid (12), and methyl galloate (13) were isolated from the leaves ofArdisia insularis. Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on three cancer cell lines namely A-549 (human lung cancer), HT-29 (Human colon adenocarcinoma), and OVCAR (human ovarian carcinoma). The results revealed that compound1inhibited A-549, HT-29, and OVCAR cell lines with IC50values of 8.5 ± 1.2, 16.4 ± 3.1, and 13.6 ± 2.4 μM, respectively. The remaining compound showed weak cytotoxic activity. This result indicated that compound1could be useful in the treatment of cancer disease.