Chromium allergy:: significance of both Cr(III) and Cr(VI)
Chromium allergy:: significance of both Cr(III) and Cr(VI)
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DOI：
10.1111/j.0105-1873.2003.0230.x
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发表时间：
2003-10-01
影响因子：
5.5
通讯作者：
Menné, T
中科院分区：
文献类型：
--
作者：
Hansen, MB;Johansen, JD;Menné, T
大多数研究铬过敏的研究都是用Cr（VI）进行的。然而，来自皮革产品的真实的铬暴露包括Cr（III）和Cr（VI）。我们已经确定并比较了Cr（VI）敏感患者中Cr（III）和Cr（VI）的最低激发阈值（MET）浓度。此外，将对Cr（III）和Cr（VI）的组合的反应与单独由Cr（III）和Cr（VI）引起的反应进行比较。在18例患者背部Finn Chambers（R）中应用Cr（III）和Cr（VI）系列稀释液。将贴片放置2天，并在第2、3和7天进行读数。根据剂量-反应曲线计算出Cr（III）和Cr（VI）的MET 10%为0.18 μ g/cm（2）/48 h（6 p. p.m.）和0.03 mug/cm（2）/48 h（下午1点），分别Cr（III）和Cr（VI）混合溶液与单一溶液的反应无显著差异，得出结论，Cr（III）在铬过敏中起重要作用，因为Cr（III）和Cr（VI）在低浓度下都能引起湿疹。与其将铬皮炎视为单独的Cr（VI）过敏的结果，不如将其视为Cr（III）和Cr（VI）联合过敏的结果。
Most studies investigating chromium allergy have been performed with Cr(VI). However, real exposure to chromium from leather products includes both Cr(III) and Cr(VI). We have determined and compared the minimum elicitation threshold (MET) concentration for Cr(III) and Cr(VI) in Cr(VI)-sensitive patients. In addition, reactions to combinations of Cr(III) and Cr(VI) were compared to reactions elicited by Cr(III) and Cr(VI) alone. Dilution series of Cr(III) and Cr(VI) were applied in Finn Chambers(R) on the back of 18 patients. The patches were left for 2 days and readings were done on days 2, 3 and 7. The MET10% for Cr(III) and Cr(VI) was calculated from the dose-response curves to be 0.18 mug/cm(2)/48 h (6 p.p.m.) and 0.03 mug/cm(2)/48 h (1 p.p.m.), respectively. No significant differences in the response to combined Cr(III) and Cr(VI) solutions versus single solutions were found. Cr(III) was concluded to play an important role in chromium allergy, because Cr(III) and Cr(VI) were both capable of eliciting eczema at low concentrations. Rather than regarding chromium dermatitis as a result of Cr(VI) allergy alone, it may be more correct to consider it as a result of a combined Cr(III) and Cr(VI) allergy.