The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications
The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications
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DOI：
10.3275/6564
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发表时间：
2010-02-01
影响因子：
5.4
通讯作者：
Altuntas, Y.
中科院分区：
文献类型：
--
作者：
Fenercioglu, A. Kutan;Saler, T.;Altuntas, Y.
背景：糖尿病高血糖引起的氧化应激是心血管并发症发生的主要因素。酚类化合物是有效的抗氧化剂，可以逆转导致糖尿病心血管并发症的因素。本研究的目的是确定一种含有石榴提取物、绿茶提取物和抗坏血酸的富含多酚的抗氧化剂补充剂对2型糖尿病患者氧化应激的拮抗作用。材料和方法：共有114名男性和女性非吸烟者(56名研究，58名安慰剂)患有2型糖尿病且没有任何并发症。在试验开始和结束时检测空腹血糖、糖化血红蛋白、低密度脂蛋白、高密度脂蛋白、甘油三酯、血浆丙二醛(MDA)、总谷胱甘肽(GSH)、过氧化氢和抗氧化能力(AOC)。组间资料变化差异采用Mann-Whitney U检验进行统计学分析。结果：研究组低密度脂蛋白降低，高密度脂蛋白升高，与安慰剂组比较差异有统计学意义(P
Background: The hyperglycemia-induced oxidative stress in diabetes mellitus (DM) is the major factor in the pathogenesis of cardiovascular complications. The phenolic compounds are potent antioxidants that can reverse the factors leading to cardiovascular complications in DM. The aim of this study was to determine the antagonizing effects of a polyphenol-rich antioxidant supplement containing pomegranate extract, green tea extract, and ascorbic acid, on oxidative stress in Type 2 diabetic patients. Materials and methods: A total of 114 male and female non-smokers (56 study, 58 placebo) with Type 2 DM and without any complications were recruited. The blood levels of fasting blood glucose, glycated hemoglobin, LDL, HDL, triglycerides, plasma malondialdehyde (MDA), total glutathione (GSH), hydrogen peroxide, and antioxidant capacity (AOC) were determined at the beginning and at the end of the 3-month trial. The differences of the data changes between the groups were statistically analyzed by Mann-Whitney U test. Results: The study group showed a decrease in LDL and an increase in HDL and the comparison with the difference in placebo group was statistically significant (p