Cadherins and synaptic plasticity.
Cadherins and synaptic plasticity.
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DOI：
10.1016/j.ceb.2008.06.003
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发表时间：
2008-10
影响因子：
7.5
通讯作者：
C. Tai;SallyA . Kim;E. Schuman
中科院分区：
文献类型：
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作者：
C. Tai;SallyA . Kim;E. Schuman
鉴于其跨突触定位、其在成熟突触处的持续表达以及其独特的生物化学和粘附特性，钙粘蛋白在突触处独特地平衡以介导突触可塑性，即改变突触功能的能力，其被认为是学习和记忆的基础。例如，最近的研究表明，钙粘蛋白可以通过直接相互作用或通过复合物形成在突触处募集和稳定AMPA受体，揭示了突触后信号传导和粘附之间的串扰。此外，使用小干扰RNA敲低钙粘蛋白，N-钙粘蛋白缺陷的胚胎干细胞的可用性和钙粘蛋白的功能与肽的应用在体内的急性中断允许更精确的解剖的分子机制，其中钙粘蛋白的功能在结构和功能的可塑性。
Given their trans-synaptic localization, their persistent expression at mature synapses and their distinct biochemical and adhesive properties, cadherins are uniquely poised at the synapse to mediate synaptic plasticity, the ability to change synaptic function thought to underlie learning and memory. For example recent work suggests that cadherins may recruit and stabilize AMPA receptors at the synapse via direct interactions or through complex formation, revealing cross talk between postsynaptic signaling and adhesion. Moreover, the use of small interfering RNA knockdown of cadherin, the availability of N-cadherin-deficient embryonic stem cells and the acute disruption of cadherin function with peptide application in vivo have allowed for more precise dissection of the molecular mechanisms by which cadherins function in both structural and functional plasticity.