RXR gamma null mice are apparently normal and compound RXR alpha(+/-)/RXR beta(-/-)/RXR gamma(-/-) mutant mice are viable
RXR gamma null mice are apparently normal and compound RXR alpha(+/-)/RXR beta(-/-)/RXR gamma(-/-) mutant mice are viable
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DOI：
10.1073/pnas.93.17.9010
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发表时间：
1996-08-20
影响因子：
11.1
通讯作者：
Chambon, P
中科院分区：
文献类型：
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作者：
Krezel, W;Dupe, V;Chambon, P
RXR γ（RXR，类维生素A X受体）基因在小鼠中被破坏。纯合子突变小鼠发育正常，在动物设施中的生长、生育力、活力和表观行为方面与其RXR γ（+/-）或野生型同窝小鼠无区别。此外，RXR α（-/-）/RXR γ（-/-）和RXR β（-/-）/RXR γ（-/-）突变体表型分别与RXR α（-/-）和RXR β（-/-）突变体的表型不可区分。引人注目的是，RXR α（+/-）/RXR β（-/-）/RXR γ（-/-）三重突变体是可行的。似乎RXR γ不发挥RXR α或RXR β不能发挥的任何基本功能，并且RXR α的一个拷贝足以发挥RXR的大部分功能。
The RXR gamma (RXR, retinoid X receptor) gene was disrupted in the mouse. Homozygous mutant mice developed normally and were indistinguishable from their RXR gamma(+/-) or wild-type littermates with respect to growth, fertility, viability, and apparent behavior in the animal facility. Moreover, RXR alpha(-/-)/RXR gamma(-/-) and RXR beta(-/-)/RXR gamma(-/-) mutant phenotypes were indistinguishable from those of RXR alpha(-/-) and RXR beta(-/-) mutants, respectively, Strikingly, RXR alpha(+/-)/RXR beta(-/-)/RXR gamma(-/-) triple mutants were viable, Thus, it appears that RXR gamma does not exert any essential function that cannot be performed by RXR alpha or RXR beta, and one copy of RXR alpha is sufficient to perform most of the functions of the RXRs.