Overlapping clusters of gray matter deficits in paranoid schizophrenia and psychotic bipolar mania with family history
Overlapping clusters of gray matter deficits in paranoid schizophrenia and psychotic bipolar mania with family history
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有家族史的偏执型精神分裂症和精神病性双相躁狂症中灰质缺陷的重叠簇
DOI：
10.1016/j.neulet.2010.11.073
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发表时间：
2011-02-04
影响因子：
2.5
通讯作者：
Li, Tao
中科院分区：
文献类型：
--
作者：
Cui, Liqian;Li, Mingli;Li, Tao
本研究的目的是评估偏执型精神分裂症患者或双相躁狂症患者与对照组相比全脑灰质的体积异常。我们获取了23例偏执型精神分裂症患者、24例精神病性双相躁狂症患者和36例健康对照者的加权3D T1磁共振图像。使用优化的基于体素的形态测量学（VBM）评估灰质体积差异。偏执型精神分裂症组和双相躁狂症组均显示颞上回（STG）（布罗德曼区22区）和顶下小叶的灰质体积减少，以及壳核增大，尽管两组中顶下小叶和壳核受影响的部位不同。我们的研究结果表明，偏执型精神分裂症和精神病性双相躁狂症存在灰质缺失的重叠区域。这两种疾病之间灰质病理的重叠可能归因于两种疾病共有的危险因素。（C）2010爱思唯尔爱尔兰有限公司。保留所有权利。
The purpose of this study was to assess volumetric abnormalities of gray matter throughout the entire brain in patients with paranoid schizophrenia or with bipolar mania compared with control groups. We obtained weighted 3D T1 magnetic resonance images from 23 patients with paranoid schizophrenia, 24 patients with psychotic bipolar mania, and 36 healthy controls. Gray matter volume differences were assessed using optimized volumetric voxel-based morphometry (VBM). Both paranoid schizophrenia and bipolar mania group showed reduction of gray matter volume in the superior temporal gyrus (STG) (Brodmann Area, BA 22 areas), and the inferior parietal lobule, and enlargement of putamen, although different sides of the inferior parietal lobule and putamen were affected in the groups. Our findings showed the presence of overlapping clusters of gray matter deficits in paranoid-type schizophrenia and psychotic bipolar mania. The overlap in gray matter pathology between the two disorders may be attributed to risk factors common to both disorders. (C) 2010 Elsevier Ireland Ltd. All rights reserved.