Digoxin- and digitoxin-induced changes in monophasic action potential of the right ventricle of the dog heart.
Digoxin- and digitoxin-induced changes in monophasic action potential of the right ventricle of the dog heart.
复制标题
地高辛和洋地黄毒苷引起的狗心脏右心室单相动作电位的变化。
DOI：
10.1093/cvr/14.3.130
复制
发表时间：
1980
影响因子：
10.8
通讯作者：
H. Watanabe
中科院分区：
文献类型：
--
作者：
J. Amlie;L. Storstein;H. Watanabe
在8小时的观察期内，观察了洋地黄毒素和地高辛对正常犬右室单相动作电位的影响。采用戊巴比妥钠麻醉，用吸电极技术记录单相动作电位。6只狗静脉注射2.0毫克地高辛，2只狗静脉注射2.0毫克地高辛，5只狗静脉注射1.0毫克地高辛，导致90%复极所需时间迅速增加，并在20至30分钟后恢复到控制值。洋地黄毒素作用2-4小时后，复极次数增加50%和90%，而地高辛则无此作用。晚期动作电位延长效应与早期消除阶段(注射后2~8h)的血药浓度呈负相关，在观察期末达到最大值。因此，洋地黄毒素和地高辛对正常犬心室单相动作电位的迟发作用不同，可能具有不同的抗心律失常活性。
The effects of digitoxin and digoxin on right ventricular monophasic action potentials were studied in intact dogs during an 8 hour observation period. Pentobarbital anaesthesia was used, and monophasic action potential recordings were obtained with the suction electrode technique. Intravenous injection of 2.0 mg digitoxin to six dogs, 2.0 mg digoxin to two dogs and 1.0 mg digoxin to five dogs caused a rapid increase in the time taken for 90% repolarisation with return to control values after 20 to 30 min. A late increase in 50 and 90% repolarisation times was observed 2 to 4 h after digitoxin, while digoxin had no such effect. The late action potential prolonging effect was inversely correlated to serum concentrations in the early elimination phase (2 to 8 h after the injection) since it reached a maximum towards the end of the observation period. Digitoxin and digoxin thus differed in their late effects on ventricular monophasic action potentials in intact dogs and may possess different antiarrhythmic activity.