Creating a False Memory in the Hippocampus
Creating a False Memory in the Hippocampus
复制标题
DOI：
10.1126/science.1239073
复制
发表时间：
2013-07-26
期刊：
影响因子：
56.9
通讯作者：
Tonegawa, Susumu
中科院分区：
文献类型：
--
作者：
Ramirez, Steve;Liu, Xu;Tonegawa, Susumu
记忆是不可靠的。我们通过光遗传学操纵海马体中的记忆印记细胞，在小鼠中创造了一个错误的记忆。齿状回（DG）或CA 1神经元暴露于一个特定的背景下被激活的标记与通道视紫红质-2。这些神经元后来在不同的背景下在恐惧条件反射过程中被光学重新激活。DG实验组在原始环境中表现出增加的冻结，其中从未传递足部电击。这种错误记忆的回忆是特定于情境的，激活了与自然恐惧记忆回忆相似的下游区域，也能够驱动积极的恐惧反应。我们的数据表明，通过人工手段产生内部表征和行为表达的恐惧记忆是可能的。
Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram-bearing cells in the hippocampus. Dentate gyrus (DG) or CA1 neurons activated by exposure to a particular context were labeled with channelrhodopsin-2. These neurons were later optically reactivated during fear conditioning in a different context. The DG experimental group showed increased freezing in the original context, in which a foot shock was never delivered. The recall of this false memory was context-specific, activated similar downstream regions engaged during natural fear memory recall, and was also capable of driving an active fear response. Our data demonstrate that it is possible to generate an internally represented and behaviorally expressed fear memory via artificial means.