Pd-Catalyzed Synthesis of Aryl Amines via Oxidative Aromatization of Cyclic Ketones and Amines with Molecular Oxygen
Pd-Catalyzed Synthesis of Aryl Amines via Oxidative Aromatization of Cyclic Ketones and Amines with Molecular Oxygen
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DOI：
10.1021/ol3027279
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发表时间：
2012-11-02
期刊：
影响因子：
5.2
通讯作者：
Li, Chao-Jun
中科院分区：
文献类型：
--
作者：
Girard, Simon A.;Hu, Xiong;Li, Chao-Jun
钯催化的分子间好氧脱氢芳构化反应已被开发用于胺与非芳酮的芳构化反应。在优化后的反应条件下，在pd催化剂的存在下，伯胺和仲胺与环己酮和2-环己烯-1-酮选择性芳化，收率较高。
Pd-catalyzed intermolecular aerobic dehydrogenative aromatizations have been developed for the arylation of amines with nonaromatic ketones. Under optimized reaction conditions, primary and secondary amines are selectively arylated in good yields with cyclohexanones and 2-cyclohexen-1-ones in the presence of a Pd-catalyst under an atmosphere of molecular oxygen.