The importance of repairing stalled replication forks
The importance of repairing stalled replication forks
复制标题
DOI：
10.1038/35003501
复制
发表时间：
2000-03-02
期刊：
影响因子：
64.8
通讯作者：
Marians, KJ
中科院分区：
文献类型：
--
作者：
Cox, MM;Goodman, MF;Marians, KJ
细菌SOS反应异常水平的DNA损伤已被确认和研究了几十年。在正常生长条件下重建失活复制叉的途径受到的关注要少得多。在不存在SOS诱导条件下有氧生长的细菌中，许多复制叉遇到DNA损伤，导致失活。叉再激活的途径涉及同源重组系统，是非诱变性的，并且整合了DNA代谢的几乎每个方面。在使用频率的基础上，这些途径代表了细菌DNA重组系统的主要功能，以及与复制和位点特异性重组相关的许多其他酶系统的主要功能。
The bacterial SOS response to unusual levels of DNA damage has been recognized and studied for several decades. Pathways for re-establishing inactivated replication forks under normal growth conditions have received far less attention. In bacteria growing aerobically in the absence of SOS-inducing conditions, many replication forks encounter DNA damage, leading to inactivation. The pathways for fork reactivation involve the homologous recombination systems, are nonmutagenic, and integrate almost every aspect of DNA metabolism. On a frequency-of-use basis, these pathways represent the main function of bacterial DNA recombination systems, as well as the main function of a number of other enzymatic systems that are associated with replication and site-specific recombination.