Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species
Inhibition of leukotriene biosynthesis by stilbenoids from Stemona species
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DOI：
10.1021/np0497043
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发表时间：
2005-01-01
影响因子：
5.1
通讯作者：
Bauer, R
中科院分区：
文献类型：
--
作者：
Adams, M;Pacher, T;Bauer, R
在基于活化的人中性粒细胞的离体测试系统中，测试了来自百部、晚香玉和佩氏百部的 15 种二苯乙烯类化合物和两种生物碱，以及市售的二苯乙烯类化合物白藜芦醇和松西素，以抑制白三烯的形成。芪类化合物白藜芦醇(1)、松诺西林(2)、二氢松西林(3)、替诺斯坦明A(4)、替诺斯坦明B(5)、替诺斯坦明D(6)、替诺斯坦明F(7)、替诺斯坦明G(8)、呋喃B(9)、呋喃C(10)、呋喃D(11)， Stemanthrene G (12)、Stemofuran J (13)、Stemanthrene A (14)、Stemanthrene B (15)、Stemanthrene C (16) 和 Stemanthrene D (17) 显示结构依赖性活性，IC(50) 值范围为 3.7 至 > 50 muM。生物碱块百部碱 (18) 和新块百部碱 (19) 在浓度为 50 μM 时无活性。
Fifteen stilbenoids and two alkaloids from Stemona collinsae, S. tuberosa, and S. peirrei were tested alongside the commercially available stilbenoids resveratrol and pinosylvin for inhibition of leukotriene formation in an ex vivo test system based on activated human neutrophilic granulocytes. The stilbenoids resveratrol (1), pinosylvin (2), dihydropinosylvin (3), stilbostemin A (4), stilbostemin B (5), stilbostemin D (6), stilbostemin F (7), stilbostemin G (8), stemofuran B (9), stemofuran C (10), stemofuran D (11), stemofuran G (12), stemofuran J (13), stemanthrene A (14), stemanthrene B (15), stemanthrene C (16), and stemanthrene D (17) showed structure-dependent activities with IC(50) values ranging from 3.7 to > 50 muM. The alkaloids tuberostemonine (18) and neotuberostemonine (19) were inactive at a concentration of 50 muM.