Natural history and prognostic factors in 305 Swedish patients with primary sclerosing cholangitis
Natural history and prognostic factors in 305 Swedish patients with primary sclerosing cholangitis
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DOI：
10.1136/gut.38.4.610
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发表时间：
1996-04-01
期刊：
影响因子：
24.5
通讯作者：
Lindberg, G
中科院分区：
文献类型：
--
作者：
Broome, U;Olsson, R;Lindberg, G
原发性硬化性胆管炎（PSC）的病程是高度可变和不可预测的。本研究描述了PSC的自然史和结果。这些数据被用来构建一个预后模型，PSC患者。方法，共305名瑞典PSC患者进行了研究。中位随访时间为63（1-194）个月，所有患者均可追踪随访。大约79名患者死亡或接受了肝脏移植。在诊断时的临床，生化和组织学结果的预后意义进行了评估，使用多变量analysis.Results-The估计的中位生存时间从诊断死亡或肝移植的时间为12年。24例（8%）患者发现胆管癌，134例（44%）患者在诊断时无症状。无症状组的估计生存率显著高于无症状组（p
Background/Aims-The course primary sclerosing cholangitis (PSC) is highly variable and unpredictable. This study describes the natural history and outcome of PSC. These data were used to construct a prognostic model for patients with PSC.Methods-A total of 305 Swedish patients with PSC were studied. The median follow up time was 63 (1-194) months and all patients could be traced for follow up. Some 79 patients died or had a liver transplant. The prognostic significance of clinical, biochemical, and histological findings at the time of diagnosis were evaluated using multivariate analysis.Results-The estimated median survival from time of diagnosis to death or liver transplantation was 12 years. Cholangiocarcinoma was found in 24 (8%) of the patients and 134 (44%) of the patients were asymptomatic at the time of diagnosis. The estimated survival rate was significantly higher in the asymptomatic group (p