SELECTION OF SUCCESSIVE TUMOR LINES FOR METASTASIS
SELECTION OF SUCCESSIVE TUMOR LINES FOR METASTASIS
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DOI：
10.1038/newbio242148a0
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发表时间：
1973-01-01
期刊：
影响因子：
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通讯作者：
FIDLER, IJ
中科院分区：
文献类型：
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作者：
FIDLER, IJ
转移的发病机制始于源自原发癌的细胞侵入组织、血管和/或脉管。在它们释放到循环中之后，大多数肿瘤栓子最初在遇到的第一个毛细血管床中被捕获，但一些再循环并被困在其他器官中。在最初的停滞之后，肿瘤细胞必须侵入实质，建立微环境，逃避宿主防御机制，最终生长成继发性肿瘤1。
The pathogenesis of metastasis begins with the invasion of tissues, blood vessels and/or lymphatics by cells originating from a primary cancer. Following their release into the circulation, most tumour emboli are initially arrested in the first capillary bed encountered, but some recirculate and are trapped in other organs. After their initial arrest, tumour cells must invade the parenchyma, establish a micro-environment, escape host defence mechanisms and finally grow into secondary tumours1.