Enhanced Tumor Accumulation of Multimodal Magneto-Plasmonic Nanoparticles via an Implanted Micromagnet-Assisted Delivery Strategy.
Enhanced Tumor Accumulation of Multimodal Magneto-Plasmonic Nanoparticles via an Implanted Micromagnet-Assisted Delivery Strategy.
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通过植入微磁体辅助递送策略增强多模式磁等离子体纳米颗粒的肿瘤积累。
DOI：
10.1002/adhm.202201585
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发表时间：
2023
影响因子：
10
通讯作者：
Mishra,Shruti
中科院分区：
文献类型：
--
作者：
Panikkanvalappil,SajanlalR;Bhagavatula,SharathK;Deans,Kyle;Jonas,Oliver;Rashidian,Mohammad;Mishra,Shruti
纳米载体辅助癌症治疗策略的主要缺点之一仍然是全身施用的纳米制剂的肿瘤渗透和保留不足及其脱靶毒性。纳米制剂的渗透性和滞留效应增强以及理化性质的基质参数相关异质性极大地导致了其肿瘤外渗不良。在本文中，证明了一种新的肿瘤靶向策略，其中肿瘤内植入的微磁体可以显著增强磁等离子体纳米颗粒（NP）在双侧结直肠肿瘤模型中微磁体植入肿瘤处的积聚，同时限制其脱靶积聚。为此，开发了由具有高治疗、传感和成像潜力的多功能部分阵列组成的新型多模态金/铁氧化物纳米颗粒。研究还发现，靶向癌细胞的纳米粒子结合静磁场可以选择性地诱导癌细胞死亡。还开发了一种多模式半胱天冬酶-3纳米传感器，用于癌细胞中选择性诱导凋亡的真实的实时可视化。此外，这些纳米粒子在体外的光热杀伤能力进行了评估，并证明其在组织样品中增强光热消融的潜力。基于目前用于治疗目的的植入式器械的使用，本研究设想拟议的微磁体辅助NP递送方法可用于加速各种纳米制剂的临床转化。
One of the major shortcomings of nano carriers‐assisted cancer therapeutic strategies continues to be the inadequate tumor penetration and retention of systemically administered nanoformulations and its off‐target toxicity. Stromal parameters‐related heterogeneity in enhanced permeability and retention effect and physicochemical properties of the nanoformulations immensely contributes to their poor tumor extravasation. Herein, a novel tumor targeting strategy, where an intratumorally implanted micromagnet can significantly enhance accumulation of magneto‐plasmonic nanoparticles (NPs) at the micromagnet‐implanted tumor in bilateral colorectal tumor models while limiting their off‐target accumulation, is demonstrated. To this end, novel multimodal gold/iron oxide NPs comprised of an array of multifunctional moieties with high therapeutic, sensing, and imaging potential are developed. It is also discovered that cancer cell targeted NPs in combination with static magnetic field can selectively induce cancer cell death. A multimodal caspase‐3 nanosensor is also developed for real‐time visualization of selective induction of apoptosis in cancer cells. In addition, the photothermal killing capability of these NPs in vitro is evaluated, and their potential for enhanced photothermal ablation in tissue samples is demonstrated. Building on current uses of implantable devices for therapeutic purposes, this study envisions the proposed micromagnet‐assisted NPs delivery approach may be used to accelerate the clinical translation of various nanoformulations.