Association of Helicobacter pylori antioxidant activities with host colonization proficiency.
Association of Helicobacter pylori antioxidant activities with host colonization proficiency.
复制标题
幽门螺杆菌抗氧化活性与宿主定植能力的关联。
DOI：
10.1128/iai.71.1.580-583.2003
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发表时间：
2003
影响因子：
3.1
通讯作者：
Maier,RobertJ
中科院分区：
文献类型：
--
作者：
Olczak,AdrianaA;SeylerJr,RichardW;Olson,JonathanW;Maier,RobertJ
To assess the importance of two separate antioxidant activities inHelicobacter pylori, we tested the abilities of strains with mutations in eithertpx(encoding thiolperoxidase) orahpC(encoding alkyl hydroperoxide reductase [AhpC]) to colonize the stomachs of mice. Thetpxstrain was clearly more sensitive than the parent strain to both oxygen and cumene hydroperoxide. The strain colonized only 5% of the inoculated mice. Two different classes of oxygen-sensitiveahpCmutants in the type strain (ATCC 43504) were recently described (A. A. Olczak, J. W. Olson, and R. J. Maier, J. Bacteriol. 184:3186-3193, 2002). The same two classes of mutants were recovered uponahpCmutagenesis of the mouse-adapted strain, SS1. Neither of these mutants was able to colonize mouse stomachs, whereas 78% of the mice inoculated with the parent strain becameH. pyloripositive.
