GAMMA-AMINOBUTYRIC ACID-CONTAINING BASAL FOREBRAIN NEURONS INNERVATE INHIBITORY INTERNEURONS IN THE NEOCORTEX
GAMMA-AMINOBUTYRIC ACID-CONTAINING BASAL FOREBRAIN NEURONS INNERVATE INHIBITORY INTERNEURONS IN THE NEOCORTEX
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DOI：
10.1073/pnas.89.2.738
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发表时间：
1992-01-15
影响因子：
11.1
通讯作者：
MESKENAITE, V
中科院分区：
文献类型：
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作者：
FREUND, TF;MESKENAITE, V
基底前脑-新皮质通路参与高级认知加工、选择性注意和觉醒，被认为是功能上最重要的皮质下上行投射之一。这种相对稀疏的皮层下通路可以控制整个皮层套中神经元活动模式的机制仍然未知。本研究提供的证据表明，在猫的γ-氨基丁酸的基底前脑神经元参与新皮质的投射，并建立多个突触连接的γ-氨基丁酸释放的中间神经元含有生长抑素或小清蛋白。我们提出，数字上小的上升通路可以在新皮层中发挥强大的全球效应的机制是通过γ-氨基丁酸释放中间神经元的选择性神经支配，这反过来又控制了大量锥体细胞通过其广泛的轴突arborizations的活动。最后，这些结果表明，在阿尔茨海默病病理学中涉及的两个细胞群之间存在直接的解剖学联系：基底前脑神经元和皮质生长抑素细胞。
The basal forebrain-neocortex pathway-involved in higher cognitive processing, selective attention, and arousal-is considered one of the functionally most important ascending subcortical projections. The mechanism by which this relatively sparse subcortical pathway can control neuronal activity patterns in the entire cortical mantle is still unknown. The present study in the cat provides evidence that gamma-aminobutyric acid-containing basal forebrain neurons participate in the neocortical projection and establish multiple synaptic connections with gamma-aminobutyric acid-releasing interneurons containing somatostatin or parvalbumin. We propose that a mechanism by which the numerically small ascending pathways can exert a powerful global effect in the neocortex is by the selective innervation of gamma-aminobutyric acid-releasing interneurons, which, in turn, control the activity of large populations of pyramidal cells through their extensive axon arborizations. Finally, these results demonstrate a direct anatomical link between two cell populations implicated in Alzheimer disease pathology: basal forebrain neurons and cortical somatostatin cells.