Association of overall survival in patients with newly diagnosed glioblastoma with contrast-enhanced perfusion MRI: Comparison of intraindividually matched T1- and T2*-based bolus techniques
Association of overall survival in patients with newly diagnosed glioblastoma with contrast-enhanced perfusion MRI: Comparison of intraindividually matched T1- and T2*-based bolus techniques
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DOI：
10.1002/jmri.24756
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发表时间：
2015-07-01
影响因子：
4.4
通讯作者：
Heiland, Sabine
中科院分区：
文献类型：
--
作者：
Bonekamp, David;Deike, Katerina;Heiland, Sabine
为了比较个体内动态磁敏感对比（DSC）和动态对比增强（DCE）MR灌注参数，并确定DCE参数与新诊断胶质母细胞瘤患者总生存期（OS）的相关性，并建立DSC参数脑血容量（CBV）的预测值。包括在37名后来诊断为胶质母细胞瘤的患者（25名男性，12名女性，39-83岁，中位数65）中在3.0特斯拉下进行的术前扫描。所有患者均接受标准治疗，包括手术和放化疗。图像进行空间配准和最大区域的利益为基础的DCE和DSC参数测量比较和阈值确定使用多元线性回归，皮尔逊相关系数和使用接收器操作特性分析。生存分析采用Kaplan-Meier曲线。（>0.29 min（-1）; P = 0.041）和CBV（>23.7 mL/100 mL; P < 0.001）与OS显著相关，与K-transs升高相比，CBV升高与更差的OS相关。K-transs与渗漏校正因子K-transs显著相关。结论DSC和DCE MR灌注联合应用可为胶质母细胞瘤患者的生存预测提供额外的预后信息。由于K-transs与CBV没有紧密耦合，这两个参数可能反映了胶质母细胞瘤生长的发病顺序的不同阶段。J.磁共振Imaging 2015;42：87-96. (c)2014年威利期刊公司
BackgroundTo compare intraindividual dynamic susceptibility contrast (DSC) and dynamic contrast enhanced (DCE) MR perfusion parameters and determine the association of DCE parameters with overall survival (OS) with the established predictive DSC parameter cerebral blood volume (CBV) in patients with newly diagnosed glioblastoma.MethodsPerfusion data were analyzed retrospectively, and included scans performed preoperatively at 3.0 Tesla in 37 patients (25 males, 12 females, 39-83 years, median 65) later diagnosed with glioblastoma. All patients received standard treatment consisting of surgery and radiochemotherapy. Images were spatially coregistered and maximum region of interest-based DCE and DSC parameter measurements compared and thresholds identified using multivariate linear regression, Pearson's correlation coefficients and using receiver operating characteristic analysis. Survival analysis was performed using Kaplan-Meier curves.ResultsWhile both, elevated volume transfer constant (K-trans) (>0.29 min(-1); P = 0.041) and CBV (>23.7 mL/100 mL; P < 0.001) were significantly associated with OS, elevated CBV was associated with worse OS compared with elevated K-trans. K-trans was significantly correlated with the leakage correction factor K-2 but not with CBV.ConclusionThe combined use of DSC and DCE MR perfusion may provide additional information of prognostic value for glioblastoma patient survival prediction. As K-trans was not tightly coupled to CBV, both parameters may reflect different stages in the pathogenetic sequence of glioblastoma growth. J. Magn. Reson. Imaging 2015;42:87-96. (c) 2014 Wiley Periodicals, Inc.