CGRP-Mediated Prolactin Upregulation: a Possible Pathomechanism in IgG4-Related Disease
CGRP-Mediated Prolactin Upregulation: a Possible Pathomechanism in IgG4-Related Disease
复制标题
CGRP 介导的催乳素上调：IgG4 相关疾病的可能病理机制
DOI：
10.1007/s10753-020-01350-6
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发表时间：
2020-10-16
期刊：
影响因子：
5.1
通讯作者：
Gao, Feng
中科院分区：
文献类型：
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作者：
Liu, Qicai;Lin, Yunfeng;Gao, Feng
与其他免疫介导的疾病类似，IgG4相关疾病（IgG4 - RD）是在接触外源性或内源性抗原的遗传易感个体中发生的疾病。在本研究中，通过免疫荧光法（IFA）证实IgG4 - RD患者血清中可检测到髓鞘相关糖蛋白（MAG）抗体（IgG、IgG4和IgM）。在体内，降钙素基因相关肽（CGRP）（+/-）大鼠的催乳素和Th2细胞因子水平高于野生型。我们的研究结果表明，CGRP缺乏介导的MAG抗体的存在可能是IgG4 - RD免疫反应中通过催乳素上调引发初始事件的分子基础。
AbstractSimilar to other immune-mediated diseases, IgG4-related disease (IgG4-RD) is the disease that develops in genetically susceptible individuals exposed to external or endogenous antigens. In the present study, it was confirmed that MAG (myelin-associated glycoprotein) antibodies (IgG, IgG4, and IgM) were detected by immunofluorescence (IFA) in serum of the patients with IgG4-RD.In vivo, the levels of prolactin and Th2 cytokines in CGRP+/−rats were higher than those in wild-type. Our findings indicate that the presence of CGRP-deficiency-mediated MAG antibodies is a probable molecular basis for the initial events which were triggered in IgG4-RD immune responses via prolactin upregulation.