Optimising surveillance for relapse of Wilms' tumour.
Optimising surveillance for relapse of Wilms' tumour.
复制标题
优化维尔姆斯肿瘤复发的监测。
DOI：
10.1016/s1470-2045(18)30440-6
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Lovvorn3rd,HaroldN
中科院分区：
文献类型：
--
作者：
Lovvorn3rd,HaroldN
肾母细胞瘤是全世界儿童中最常见的肾癌，在发达国家，5年总生存率超过90%。1虽然只有少数（约15%）肾母细胞瘤复发的患者，但这些儿童的挽救治疗具有挑战性，需要高度强化的治疗，仅对约一半的患者有效。2，3复发的幸存者可能会有终身的健康问题，并有继发性恶性肿瘤的风险，从有毒的治疗方案，这要求改善治疗与细胞特异性活性和更少的脱靶后遗症。4更清楚地了解导致对Wilms肿瘤多模式治疗产生耐药性的生物学以及早期临床检测其复发是治疗儿科癌症的合作小组强调的原则。5，6 Jesper Brok和同事在《柳叶刀肿瘤学》上发表的文章7中报告了威尔姆斯肿瘤的复发模式，并批判性地分析了迄今为止用于检测该肿瘤的方法，无论是通过常规监测成像还是评估预定访视之间出现的临床症状。作者提供了一种新的算法来优化Wilms肿瘤复发的早期检测，这可以提高挽救率并简化宝贵医疗资源的使用。正如他们在文章中所建议的那样，
Wilms’ tumour is the most common kidney cancer in children worldwide and, in developed countries, overall survival exceeds 90% at 5 years. 1 Although only a minority (around 15%) of patients with Wilms’ tumour relapse, salvage therapy for these children is challenging, requiring highly intensive treatments that are only effective for approximately half of patients. 2, 3 Survivors of relapse can have lifelong health problems and are at risk of secondary malignant neoplasms from toxic therapeutic regimens, which mandate improved therapy with cell-specific activity and fewer off-target sequelae. 4 A clearer understanding of the biology that drives resistance to multimodal therapies for Wilms’ tumours and earlier clinical detection of its relapse are principles emphasised in cooperative groups that treat pediatric cancers. 5, 6In their Article7 published in The Lancet Oncology, Jesper Brok and colleagues report the relapse pattern of Wilms’ tumour and critically analyse the methods used for its detection until now, whether through routine surveillance imaging or upon evaluation of clinical symptoms arising between scheduled visits. The authors offer a novel algorithm to optimise early detection of Wilms’ tumour relapse, which could improve salvage rates and streamline use of precious health-care resources. As is proposed in their Article,
影响因子：
15.3
作者：
van den Heuvel-Eibrink, Marry M.;Hol, Janna A.;Graf, Norbert
通讯作者：
Graf, Norbert