Montreal Cognitive Assessment Performance in HIV/AIDS: Impact of Systemic Factors
Montreal Cognitive Assessment Performance in HIV/AIDS: Impact of Systemic Factors
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DOI：
10.1017/cjn.2015.306
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发表时间：
2016-01-01
影响因子：
3
通讯作者：
Power, Christopher
中科院分区：
文献类型：
--
作者：
Koenig, Noshin;Fujiwara, Esther;Power, Christopher
背景资料：很大一部分艾滋病毒/艾滋病感染者患有神经认知障碍。NCI的原因在HIV感染中是多方面的，尽管一部分HIV/AIDS患者受到谱系综合征（HIV相关神经认知障碍（HAND））的影响。我们调查了蒙特利尔认知评估（莫卡）与临床，人口统计学和实验室检查结果的关系，以及其预测HIV/AIDS患者症状性手（sHAND）的能力。研究方法：所有受试者均接受定期HIV护理，包括CD 4 + T细胞计数、血浆病毒载量测量、临床评估和抗逆转录病毒治疗。sHAND的诊断基于临床、神经影像学和神经心理学评估。结果：在HIV-1血清阳性受试者（n=125）中，种族、教育和就业与他们的莫卡评分呈正相关（p
Background: A large proportion of people living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) suffer from neurocognitive impairment (NCI). The causes of the NCI are multifold in HIV infection although a subset of HIV/AIDS patients are affected by the spectrum syndrome, HIV-associated neurocognitive disorder (HAND). We investigated the Montreal Cognitive Assessment (MoCA) in relation to clinical, demographic and laboratory findings as well as its ability to predict symptomatic HAND (sHAND) among patients with HIV/AIDS. Methods: All subjects were receiving regular HIV care including CD4+ T cell counts, plasma viral load measurements, clinical evaluations and antiretroviral therapy. The diagnosis of sHAND was based upon clinical, neuroimaging, and neuropsychological assessments. Results: Among HIV-1 seropositive subjects (n=125), ethnicity, education and employment were positively correlated with their MoCA scores (p