Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome
Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome
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DOI：
10.1001/jama.299.19.2287
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发表时间：
2008-05-21
影响因子：
120.7
通讯作者：
Jacobs, David R., Jr.
中科院分区：
文献类型：
--
作者：
Holvoet, Paul;Lee, Duk-Hee;Jacobs, David R., Jr.
实验数据支持氧化低密度脂蛋白（LDL）与代谢综合征相关的假设。然而，这一假设尚未在human.Objective中进行测试，以建立氧化低密度脂蛋白与代谢综合征在一般community.Design，设置，和参与者的关系冠状动脉风险发展在年轻人（CARDIA）研究是一项以人群为基础的，前瞻性，观察性研究。我们研究了1889名参与者，他们在1985年和1986年招募时年龄在18岁到30岁之间，居住在美国四个大都市中的一个。41%的美国黑人; 56%的女性），并且在第15年时（2000-2001年，年龄33-45岁）和20年的检查（2005-2006年）。氧化LDL用单克隆抗体酶联免疫吸附试验测定。代谢综合征的定义，根据成人治疗面板III的国家胆固醇教育Program.Results事件代谢综合征被诊断为在20年的后续12.9%（243 1889）的参与者谁没有代谢综合征在15年的后续。5年随访后，代谢综合征发生的优势比（OR）经年龄、性别、种族、研究中心、吸烟、体重指数、体力活动和氧化LDL五分位数的LDL胆固醇水平调整后为2.1（95%置信区间[CI]，1.1-3.8）（55.4-69.1 U/L）; 2.4（95% CI，1.3-4.3）（69.2-81.2 U/L）;第四个五分位数（81.3-97.3 U/L）为2.8（95% CI，1.5-5.1）;第五个五分位数（>= 97.4 U/L）为3.5（95% CI，1.9-6.6）。在氧化LDL最高与最低五分位数中，代谢综合征二分组分发生率的校正OR分别为腹型肥胖2.1（95% CI，1.2-3.6）、空腹血糖高2.4（95% CI，1.5-3.8）和甘油三酯高2.1（95% CI，1.1-4.0）。低密度脂蛋白胆固醇与代谢综合征或其任何组成部分在充分调整模型含有oxidized LDL.Conclusion氧化LDL浓度较高与代谢综合征的发病率增加的整体，以及其组成部分的腹部肥胖，高血糖症，高血脂症。
Context Experimental data support the hypothesis that oxidized low-density lipoprotein (LDL) is associated with the metabolic syndrome. However, this hypothesis has not been tested in humans.Objective To establish the relation of oxidized LDL with metabolic syndrome in the general community.Design, Setting, and Participants The Coronary Artery Risk Development in Young Adults (CARDIA) study is a population-based, prospective, observational study. We studied 1889 participants who were between the ages of 18 and 30 years at the time of recruitment in 1985 and 1986 and living in 1 of 4 US metropolitan areas (41% African American; 56% women) and were seen both at year 15 (2000-2001, ages 33-45 years) and year 20 examinations (2005-2006).Main Outcome Measure The longitudinal association of oxidized LDL and incident metabolic syndrome. Oxidized LDL was measured with a monoclonal antibody-based enzyme-linked immunosorbent assay. The metabolic syndrome was defined according to the Adult Treatment Panel III of the National Cholesterol Education Program.Results Incident metabolic syndrome was diagnosed at the year 20 follow-up in 12.9% (243 of 1889) of participants who did not have metabolic syndrome at the 15-year follow-up. The odds ratios (ORs) for incident metabolic syndrome after 5 years' follow-up and adjusted for age, sex, race, study center, cigarette smoking, body mass index, physical activity, and LDL cholesterol levels by quintiles of oxidized LDL were 2.1 (95% confidence interval [CI], 1.1-3.8) for the second quintile (55.4-69.1 U/L); 2.4 (95% CI, 1.3-4.3) for the third quintile (69.2-81.2 U/L); 2.8 (95% CI, 1.5-5.1) for the fourth quintile (81.3-97.3 U/L); and 3.5 (95% CI, 1.9-6.6) for the fifth quintile (>= 97.4U/L). The adjusted ORs for incidence of dichotomous components of metabolic syndrome in the highest vs the lowest quintile of oxidized LDL were 2.1 (95% CI, 1.2-3.6) for abdominal obesity, 2.4 (95% CI, 1.5-3.8) for high fasting glucose, and 2.1 (95% CI, 1.1-4.0) for high triglycerides. Low-density lipoprotein cholesterol was not associated with incident metabolic syndrome or with any of its components in the fully adjusted model containing oxidized LDL.Conclusion Higher concentration of oxidized LDL was associated with increased incidence of metabolic syndrome overall, as well as its components of abdominal obesity, hyperglycemia, and hypertriglyceridemia.