MRI evaluation of right ventricular pressure overload in chronic obstructive pulmonary disease
MRI evaluation of right ventricular pressure overload in chronic obstructive pulmonary disease
复制标题
DOI：
10.1002/jmri.1880080502
复制
发表时间：
1998-09-01
影响因子：
4.4
通讯作者：
Postmus, PE
中科院分区：
文献类型：
--
作者：
Marcus, JT;Noordegraaf, AV;Postmus, PE
慢性阻塞性肺疾病（COPD）患者常伴有肺动脉高压，本研究旨在评价COPD患者右心室压力负荷过重和右心室衰竭的征象。MR相位对比速度定量用于测量每搏输出量和现在进入和离开RV的模式。将患者的数据与年龄匹配的对照组（n = 8）的数据进行了测试，结果显示RV壁厚度增加（0.6 ± 0.1 vs 0.4 ± 0.1 cm，P <0.001）。RV质量增加（67 +/- 11 vs 57 +/- 5 g，P < .005）。RV每搏输出量减少（57 +/- 13 vs 71 +/- 13 mi，P <0.01），但RV射血分数无差异。在主肺动脉中，加速时间除以射血时间的商降低（33 +/- 5% vs 38 +/-4%，P <0.05），这表明肺动脉高压。总之，该MRI方案提供了一种在心力衰竭变得明显之前评估RV压力超负荷对COPD的影响的工具。
In chronic obstructive pulmonary disease (COPD), the development of pulmonary hypertension is common, This study was performed to assess the signs of right ventricular (RV pressure overload and RV failure in COPD, In 8 COPD patients without primary cardiac disease, RV wall thickness, mass, and end-diastolic volume were measured by cardiac-triggered cine MRI. MR phase-contrast velocity quantification was used to measure stroke volume and the patterns of now into and out of the RV. Data of patients were tested versus those of a control group matched for age (n = 8), Results showed that the RV wall thickness was increased (.6 +/- 0.1 vs 0.4 +/- 0.1 cm, P < .001). RV mass was increased (67 +/- 11 vs 57 +/- 5 g, P < .005). RV stroke volume was decreased (57 +/- 13 vs 71 +/- 13 mi, P < .01), but RV ejection fraction was not different. In the main pulmonary artery now, the quotient of acceleration time divided by ejection time was decreased (33 +/- 5% vs 38 +/- 4%, P < .05), which is indicative of pulmonary hypertension. In conclusion, this MRI protocol provides a tool to assess the effects of RV pressure overload in COPD before heart failure has become manifest.