Spontaneous pallidal neuronal activity in human dystonia: Comparison with Parkinson's disease and normal macaque
Spontaneous pallidal neuronal activity in human dystonia: Comparison with Parkinson's disease and normal macaque
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DOI：
10.1152/jn.00971.2004
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发表时间：
2005-06-01
影响因子：
2.5
通讯作者：
Turner, RS
中科院分区：
文献类型：
--
作者：
Starr, PA;Rau, GM;Turner, RS
肌张力障碍是一种运动障碍，其定义为持续的肌肉收缩，导致扭曲和重复运动以及异常姿势。为了了解肌张力障碍的苍白球放电异常，我们分析了从22例肌张力障碍患者的内部或外部苍白球（GPi或GPe）中取样的453个神经元的自发活动，11例帕金森病（PD）患者的140个神经元，以及两种正常非人灵长类动物（NHP; Macacca mulatta）的157个神经元。所有记录均在无全身镇静的情况下进行。肌张力障碍的平均GPi放电率为55.3 +/- 1.3（SE）Hz。这显著低于正常NHP（82.5 +/- 2.5 Hz）和PD患者（95.2 +/- 2.3 Hz）。肌张力障碍患者的平均GPe放电率（54.0 +/- 1.9 Hz）低于正常NHP患者（69.7 +/- 3.3 Hz），与PD患者（56.6 +/- 3.5 Hz）无法区分。平均GPi放电率与肌张力障碍严重程度呈负相关。GPi表现出增加的振荡活动在2- 10赫兹的范围内，并增加爆破活动在肌张力障碍和PD相比，正常的NHP。由于异常的放电模式是类似的肌张力障碍相比，PD，我们认为，爆裂和振荡活动叠加在一个高的背景放电率与帕金森综合征，而类似的爆裂和振荡叠加在一个较低的放电率与肌张力障碍。我们的研究结果是最一致的模型肌张力障碍的病理生理学，其中两个纹状体细胞群体的基底神经节的直接和间接的内在途径都增加了自发活动。
Dystonia is a movement disorder defined by sustained muscle contractions, causing twisting and repetitive movements and abnormal postures. To understand the abnormalities in pallidal discharge in dystonia, we have analyzed the spontaneous activity of 453 neurons sampled from the internal or external pallidum (GPi or GPe) of 22 patients with dystonia, 140 neurons from 11 patients with Parkinson's disease (PD), and 157 neurons from two normal non-human primates (NHPs; Macacca mulatta). All recordings were performed without systemic sedation. Mean GPi discharge rate in dystonia was 55.3 +/- 1.3 (SE) Hz. This was significantly lower than in the normal NHPs (82.5 +/- 2.5 Hz) and lower than in PD patients (95.2 +/- 2.3 Hz). Mean GPe discharge rate in dystonia (54.0 +/- 1.9 Hz) was lower than in the normal NHPs (69.7 +/- 3.3 Hz) and was indistinguishable from that in PD patients (56.6 +/- 3.5 Hz). Mean GPi discharge rate was inversely correlated with dystonia severity. GPi showed increased oscillatory activity in the 2- to 10-Hz range and increased bursting activity in both dystonia and PD as compared with the normal NHPs. Because the abnormalities in discharge patterns were similar in dystonia compared with PD, we suggest that bursting and oscillatory activity superimposed on a high background discharge rate are associated with parkinsonism, whereas similar bursting and oscillations superimposed on a lower discharge rate are associated with dystonia. Our findings are most consistent with a model of dystonia pathophysiology in which the two striatal cell populations contributing to the direct and indirect intrinsic pathways of the basal ganglia both have increased spontaneous activity.