Concanavalin A‐induced Suppressor Cell Activity in Lipoid Nephrosis
Concanavalin A‐induced Suppressor Cell Activity in Lipoid Nephrosis
复制标题
类脂肾病中伴刀豆球蛋白 A 诱导的抑制细胞活性
DOI：
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发表时间：
1981
影响因子：
3.7
通讯作者：
Koichi Matsumoto
中科院分区：
文献类型：
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作者：
K. Osakabe;Koichi Matsumoto
本文分析了28例脂质性肾病（LN）和1例慢性增生性肾小球肾炎（CGN）的抑制细胞活性（SCA）。我们评估了伴刀豆球蛋白A（Con A）刺激的外周血淋巴细胞（PBL）抑制正常同种异体淋巴细胞增殖反应的能力，Con A和植物血凝素（PHA）。结果发现，LN患者在复发的早期阶段有显着增加的抑制指数（SI）的水平时，与正常对照组获得的值相比。与此相反，平均抑制值在PBL LN患者缓解和CGN患者有或无肾病综合征，是否使用丝裂原是Con A或PHA，是相似的对照组。此外，当个别患者通过他们的临床疾病进行随访时。LN患者有高水平的SI，特别是在急性加重的开始，SI水平，然后急剧下降，在复发的后期，再次增加到相对正常的水平与临床缓解的开始。这些体外研究结果表明，在一组LN患者中，Con A诱导的SCA存在改变。
Suppressor cell activity (SCA) was analysed in 28 patients with lipoid nephrosis (LN) and I patients with chronic proliferative glomerulonephritis (CGN). We have assessed the ability of peripheral blood lymphocytes (PBL) stimulated by concanvalin A(Con A) to inhibit the proliferative response of normal allogeneic lymphocytes by both Con A and phytohaemagglutinin (PHA). It was found that the LN patients in the earlier phase of relapse had significantly increased levels of suppression index (SI) when compared with the values obtained with normal controls. In contrast, the mean suppression values in the PBL from LN patients in remission and CGN patients with or without nephrotic syndrome, whether the mitogen used was Con A or PHA, were similar in those of the control subjects. Moreover, when individual patients were followed through their clinical illness. LN patients had high levels of SI, particularly in the beginning of acute exacerbations; the SI levels then decreased sharply in the latter phase of relapse and again increased to relatively normal levels with the onset of clinical remission. These in vitro findings suggest that there exists an alteration in Con A‐induced SCA in a group of patients with LN.