Endosomes, receptor tyrosine kinase internalization and signal transduction
Endosomes, receptor tyrosine kinase internalization and signal transduction
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DOI：
10.1007/bf01204345
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发表时间：
1995-12-01
影响因子：
4
通讯作者：
Posner, BI
中科院分区：
文献类型：
--
作者：
Bergeron, JJM;DiGuglielmo, GM;Posner, BI
当胰岛素或表皮生长因子与肝实质质膜上的同源受体结合时，信号转导和受体内化几乎是同时发生的。事实上，配体介导的受体内化到肝脏和其他器官内体的速度和程度预示着信号转导在这个细胞内位点受到调节。虽然内化被认为是减弱配体介导的信号转导反应的一种机制，但对分离肝内体中内化受体的详细研究表明，另一种情况是，选择性信号转导通路可以在该位点进入。
Upon the binding of insulin or epidermal growth factor to their cognate receptors on the liver parenchymal plasmalemma, signal transduction and receptor internalization are near co-incident. Indeed, the rapidity and extent of ligand mediated receptor internalization into endosomes in liver as well as other organs predicts that signal transduction is regulated at this intracellular locus. Although internalization has been thought as a mechanism to attenuate ligand mediated signal transduction responses, detailed studies of internalized receptors in isolated liver endosomes suggest an alternative scenario whereby selective signal transduction pathways can be accessed at this locus.