Grape seed proanthocyanidins influence gut microbiota and enteroendocrine secretions in female ratst
Grape seed proanthocyanidins influence gut microbiota and enteroendocrine secretions in female ratst
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DOI：
10.1039/c7fo02028g
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发表时间：
2018-03-01
期刊：
影响因子：
6.1
通讯作者：
Pinent, Montserrat
中科院分区：
文献类型：
--
作者：
Casanova-Marti, Angela;Serrano, Joan;Pinent, Montserrat
葡萄籽原花青素提取物（GSPE）调节代谢综合征中涉及的几个参数。GSPE是一种化合物的混合物，一些化合物被迅速吸收，而另一些化合物则保留在管腔中，在那里它们可能会对整个生物体产生影响。我们的目的是破译GSPE的8天治疗，以前显示减少食物摄入，诱导微生物群和肠激素分泌的变化。厚壁菌门的比例：与对照组相比，GSPE处理的大鼠的微生物群中拟杆菌属较低，并且观察到几个分类科和属的差异。这种调节导致盲肠丁酸含量的减少。GSPE还增加血浆胰高血糖素样肽-1（GLP-1）。没食子酸未诱导微生物群特征或GLP-1分泌的重大变化。观察到几种微生物群分类群与血浆三酰甘油、肥胖和肠激素之间的相关性。微生物群的调节可能是GSPE影响代谢健康的机制之一。
Grape seed proanthocyanidin extract (GSPE) modulates several parameters involved in metabolic syndrome. GSPE is a mixture of compounds, some which are rapidly absorbed, while others remain in the lumen where they might have effects that are translated to the whole organism. Our aim was to decipher if the 8-day treatment of GSPE, previously shown to reduce food intake, induces changes in the micro biota and enterohormone secretion. The ratio of Firmicutes : Bacteroidetes was lower in the microbiota of GSPE-treated rats compared to controls, and differences in several taxonomic families and genera were observed. Such modulation led to a reduction in cecal butyrate content. GSPE also increased plasma glucagon-like-peptide-1 (GLP-1). Gallic acid did not induce major changes in the microbiota profile nor in GLP-1 secretion. Correlations between several microbiota taxa and plasma triacylglycerol, adiposity, and enterohormones were observed. Modulation of microbiota may be one of the mechanism by which GSPE impacts metabolic health.