Perioperative genomics.
Perioperative genomics.
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DOI：
10.1016/j.bpa.2011.09.001
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Nagele P
中科院分区：
文献类型：
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作者：
Nagele P
人类基因组计划完成十年来，人类遗传学和基因组学取得了令人难以置信的进步。这一进展在很大程度上是由更好、更快、更便宜的测序技术的可用性推动的。虽然人类基因组计划花了10年多的时间和10亿多美元才完成，但到2011年，一个人可以在一周内以不到30，000美元的价格完成他的整个基因组测序。随着更便宜和更快的测序，出现了大量的新发现，这使得及时审查这些新发现的人类基因组见解与围手术期医学相关。这篇综述总结了遗传遗传的基础知识，人类基因组和现代测序方法，以及遗传变异，以及如何将这些知识应用于围手术期的患者护理和研究。
Since the completion of the Human Genome Project 10 years ago, the world has witnessed an incredible progress in human genetics and genomics. This progress was largely driven by the availability of better, faster and cheaper sequencing technology. While it took more than 10 years and more than 1 billion dollars to complete the Human Genome Project, an individual in the year 2011 can have his whole genome sequenced within a week for less than $30,000. With cheaper and faster sequencing came a wealth of novel discoveries which makes it timely to review how these newly found insights into the human genome are relevant for perioperative medicine. This review summarizes the basics of genetic inheritance, the human genome and modern sequencing methods, as well as genetic variation and how this knowledge may be applied to patient care and research in the perioperative setting.