Suppression of the humoral antibody response in natural retrovirus infections.
Suppression of the humoral antibody response in natural retrovirus infections.
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抑制自然逆转录病毒感染中的体液抗体反应。
DOI：
10.1126/science.6302837
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Essex,M
中科院分区：
文献类型：
--
作者：
Trainin,Z;Wernicke,D;Ungar-Waron,H;Essex,M
猫白血病病毒（FeLV）通常通过诱发宿主急性感染其他病原体而不是诱导白血病而导致死亡。在先前的一项研究中，发现感染FeLV的猫具有延长的同种移植物排斥反应，但没有证据表明体液免疫反应受损。在本研究中，发现与未感染对照组相比，在自然感染FeLV的健康猫中，对合成多链多肽（L-酪氨酸-L-谷氨酸）-聚-DL-丙氨酸-聚-L-赖氨酸（表示为（T，G）AL）的体液应答显著降低。在持续FeLV病毒血症的猫中，对（T，G）AL的主要抗体应答（通常在免疫后第9 - 14天观察到）延迟并大幅降低。
The feline leukemia virus (FeLV) frequently causes death by predisposing the host to acute infections by other pathogens rather than by inducing leukemia. In a previous study, cats infected with FeLV were found to have prolonged homograft rejection responses but there was no evidence that the humoral immune response was impaired. In the present study, the humoral response to the synthetic multichain polypeptide (L-tyrosine-L-glutamic acid)-poly-DL-alanine-poly-L-lysine, denoted (T,G)AL, was found to be significantly depressed in healthy cats that were naturally infected with FeLV compared to uninfected controls. In cats with persistent FeLV viremia the major antibody response to (T,G)AL, normally seen at days 9 to 14 after immunization, was both delayed and greatly reduced.