Nucleotide sequences of the human and mouse atrial natriuretic factor genes.
Nucleotide sequences of the human and mouse atrial natriuretic factor genes.
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DOI：
10.1126/science.6542248
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发表时间：
1984-12
期刊：
影响因子：
56.9
通讯作者：
C. Seidman;K. Bloch;K. A. Klein;J. Smith;J. Seidman
中科院分区：
文献类型：
--
作者：
C. Seidman;K. Bloch;K. A. Klein;J. Smith;J. Seidman
小鼠和人心钠素（ANF）基因已被克隆并确定了其核苷酸序列。每个ANF基因由三个编码区组成，由两个插入序列隔开。5'侧翼序列和编码proANF的序列在两个物种之间高度保守，而间插序列和3'非翻译区则不保守。该基因5'端保守序列可能在ANF基因表达调控中起重要作用。
Mouse and human atrial natriuretic factor (ANF) genes have been cloned and their nucleotide sequences determined. Each ANF gene consists of three coding blocks separated by two intervening sequences. The 5' flanking sequences and those encoding proANF are highly conserved between the two species, while the intervening sequences and 3' untranslated regions are not. The conserved sequences 5' of the gene may play an important role in the regulation of ANF gene expression.