Histopathologic findings in explanted heart tissue from patients with end-stage idiopathic dilated cardiomyopathy
Histopathologic findings in explanted heart tissue from patients with end-stage idiopathic dilated cardiomyopathy
复制标题
DOI：
10.1007/s001470100339
复制
发表时间：
2001-09-01
影响因子：
3.1
通讯作者：
Galama, JMD
中科院分区：
文献类型：
--
作者：
de Leeuw, N;Ruiter, DJ;Galama, JMD
对移植的心脏进行检查，以确定终末期特发性扩张型心肌病（IDC）患者的心肌中是否存在特定的组织病理学特征。通过光学显微镜、电子显微镜和免疫组织化学进行的广泛的组织病理学检查显示，37例IDC患者中有21例心脏明显纤维化，35例已知原因的心脏病患者中有26例心脏纤维化。反应性（间质和血管周围）纤维化在IDC心脏中占主导地位，而在对照组中发现了修复性（替代）纤维化和反应性纤维化。在9例IDC患者和14例对照组患者中发现了内皮细胞弹力纤维增生症。不同的纤维化模式是IDC患者和已知原因的心脏病患者心肌样本之间唯一显著的组织病理学差异。IDC患者中弥漫性存在反应性纤维化，表明影响心肌细胞外基质组成的更广泛的功能障碍。
Explanted hearts were examined to determine whether specific histopathologic features are present in the myocardium of patients with end-stage idiopathic dilated cardiomyopathy (IDC). Extensive histopathologic examination by light microscopy, electron microscopy and immunohistochemistry revealed marked fibrosis in the hearts of 21 of 37 IDC patients and in 26 of 35 patients with heart diseases of known causes. Reactive (interstitial and perivascular) fibrosis predominated in the IDC hearts, whereas both reparative (replacement) fibrosis and reactive fibrosis were found in the comparison group. Endocardial fibroelastosis was found in nine patients with IDC and in 14 patients from the comparison group. Distinct patterns of fibrosis were the sole significant histopathologic difference between myocardial samples from patients with IDC and from those with heart diseases of known causes. The diffuse presence of reactive fibrosis in IDC patients suggests a more generalised dysfunction that affects the composition of the myocardial extracellular matrix.