Azidocillin treatment of enterococcal septicemia.
Azidocillin treatment of enterococcal septicemia.
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阿齐多西林治疗肠球菌败血症。
DOI：
10.3109/inf.1972.4.issue-2.15
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发表时间：
1972
影响因子：
--
通讯作者：
G. Tunevall
中科院分区：
文献类型：
--
作者：
E. Bengtsson;T. Strandell;M. Svanbom;G. Tunevall
本文报告了两例肠球菌败血症，用阿奇霉素（一种新的青霉素衍生物，在体外抗肠球菌作用比青霉素G和氨苄青霉素更强）治疗成功。1例胆囊切除患者出现败血症，但无心内膜炎体征。另一位在膀胱导管插入术后患上肠球菌败血症。主动脉瓣接合，随后发生瓣膜破坏和进行性心脏功能不全，手术治疗成功。两名患者目前健康状况良好。在这两种情况下，血清中的叠氮西林水平远高于所涉及的肠球菌的杀菌浓度。体外研究表明，链霉素的协同作用，但进一步的实验室和临床研究是必要的，以指导临床利用这种效果。
AbstractTwo cases of enterococcal septicemia are reported which were successfully treated with azidocillin, a new penicillin derivative more effective in vitro against enterococci than penicillin G and even ampicillin. One cholecystectomized patient had septicemia but no signs of endocarditis. The other developed enterococcal septicemia after a bladder catheterization. Aortic valve engagement followed with valvular destruction and progressive insufficiency of the heart This was successfully treated surgically. Both patients are now in a good state of health. In both cases azidocillin levels in serum were well above the bactericidal concentrations for the enterococci involved. In vitro studies demonstrated synergistic action of streptomycin, but further laboratory and clinical studies are necessary to guide a clinical exploitation of this effect.