Event-related potentials to inspiratory flow-resistive loads in young adults: stimulus magnitude effects
Event-related potentials to inspiratory flow-resistive loads in young adults: stimulus magnitude effects
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DOI：
10.1016/s0301-0511(98)00034-9
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发表时间：
1998-09-01
影响因子：
2.6
通讯作者：
Squires, NK
中科院分区：
文献类型：
--
作者：
Bloch-Salisbury, E;Harver, A;Squires, NK
在年轻成年人中，对四级吸气阻力负荷的短暂呈现记录了事件相关电位。我们根据主观感受到的阻力水平对这些负荷进行了标记：阈下（0.34厘米水柱/升每秒）、近阈（4.01厘米水柱/升每秒）、中等（10.4厘米水柱/升每秒）和近闭塞（57.5厘米水柱/升每秒）。未被察觉的阈下刺激未引发可辨别的事件相关电位，但对三个较大的刺激均观察到了事件相关电位的晚期成分（P2、N2和P3）。它们在一定程度上与刺激期间获得的行为判断有关。事件相关电位成分的潜伏期和振幅作为刺激强度的函数有系统地变化，其方式与在使用听觉和视觉刺激的事件相关电位范式中观察到的相似。因此，数据表明，呼吸相关的事件相关电位对吸气开始时存在的阻力负荷的生理效应敏感。呼吸事件相关电位可用于推断对气流阻力增加的感觉和知觉反应，因此，可能与患者群体中气流阻塞的感知有关。（C）1998年，爱思唯尔科学出版社。版权所有。
Event-related potentials were recorded to brief presentations of four levels of inspiratory flow-resistive loads in young adults. We labeled the loads according to the level of resistance they provided subjectively: sub-threshold (0.34 cmH(2)O/1 per s), near-threshold (4.01 cmH(2)O/1 per s), intermediate (10.4 cmH(2)O/1 per s), and near-occlusion (57.5 cmH(2)O/1 per s). No discernible ERPs were elicited by the undetected, sub-threshold stimulus but late components of the ERP (P2, N2, and P3) were observed to each of the three larger stimuli. They were related, in part, to behavioral judgments obtained during the stimulus periods. Both the latency and amplitude of the ERP components varied systematically as a function of stimulus magnitude, in a manner comparable to that observed in ERP paradigms using auditory and visual stimuli. Thus, the data show that event-related potentials to breathing are sensitive to physiologic effects of resistive loads present at the onset of inspiration. Respiratory ERPs may be used to infer sensory and perceptual responses to increases in airflow resistance and, accordingly, may relate to the perception of airflow obstruction in patient populations. (C) 1998 Elsevier Science B.V. All rights reserved.