Weekly versus triweekly cisplatin plus intensity-modulated radiotherapy in locally advanced nasopharyngeal carcinoma: A propensity score analysis with a large cohort.
Weekly versus triweekly cisplatin plus intensity-modulated radiotherapy in locally advanced nasopharyngeal carcinoma: A propensity score analysis with a large cohort.
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每周与每三周顺铂联合调强放疗治疗局部晚期鼻咽癌：大型队列的倾向评分分析
DOI：
10.7150/jca.26110
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发表时间：
2018
影响因子：
3.9
通讯作者：
Xia JC
中科院分区：
文献类型：
--
作者：
Zhu Q;Hu H;Tang LQ;You R;Zhao JJ;Weng DS;Pan QZ;Chen CL;Zhou ZQ;Tang Y;Xia JC
目的：直接比较调强放疗（IMRT）联合顺铂每周一次（40 mg/m2）与高剂量顺铂（100 mg/m2）每3周一次的疗效和急性毒性。材料与方法：回顾性分析了2010年1月至2013年12月中山大学附属肿瘤医院确诊的3,799例局部晚期鼻咽癌患者。进行倾向评分分析以平衡组间的基线特征，这使我们能够得出可靠的结论。然后在平衡良好的大型队列中评估疗效和安全性特征。结果如下：顺铂每周一次联合治疗的患者发生远处转移的风险低于三周一次方案治疗的患者（风险比[HR]，0.45; P = 0.028）。但是，无病生存率、局部无复发生存率和总生存率相似。每周一次组显示3-4级血小板减少症的发生率显著高于三周一次组，但3-4级粘膜炎、恶心和呕吐的发生率较低。结论：调强放疗同时每周顺铂方案与显著改善局部晚期鼻咽癌的无远处转移生存率相关。每周一次和每三周一次的顺铂方案之间的选定的急性毒性的差异。
Purpose: To directly compare the efficacy and acute toxicities of intensity-modulated radiotherapy (IMRT) concurrent with weekly cisplatin (40 mg/m2) to high-dose concurrent cisplatin (100 mg/m2) at three-week intervals. Materials and Methods: A total of 3,799 patients diagnosed with locally advanced nasopharyngeal carcinoma (NPC) at Sun Yat-Sen University Cancer Center between January 2010 and December 2013 were retrospectively reviewed. Propensity score analysis was conducted to balance the baseline characteristics between the groups, which allowed us to draw reliable conclusions. The efficacy and safety profiles were then assessed in the well-balanced large cohort. Results: The risk of distant metastasis was lower among the patients treated with weekly concurrent cisplatin than among those treated with the triweekly regimen (hazard ratio [HR], 0.45; P = .028). However, the disease-free survival, loco-regional relapse-free survival and overall survival rates were similar. The weekly group showed significantly higher rates of grade 3-4 thrombocytopenia, but lower rates of grade 3-4 mucositis, nausea and vomiting than the triweekly group. Conclusion: IMRT concurrent with a weekly cisplatin regimen was associated with significantly improved distant metastasis-free survival in locally advanced NPC. Differences in the selected acute toxicities between the weekly and triweekly concurrent cisplatin regimens were noted.
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影响因子：
5.7
作者：
Lee, Ji Yun;Sun, Jong-Mu;Ahn, Myung-Ju
通讯作者：
Ahn, Myung-Ju
影响因子：
5.7
作者：
Loong, Herbert H.;Ma, Brigette B. Y.;Chan, Anthony T. C.
通讯作者：
Chan, Anthony T. C.
DOI：
10.1097/coc.0b013e31826b9b1a
发表时间：
2014-02-01
影响因子：
2.6
作者：
Jagdis, Amanda;Laskin, Janessa;Ho, Cheryl
通讯作者：
Ho, Cheryl
DOI：
10.2349/biij.2.1.e19
发表时间：
2006-01-01
期刊：
Biomedical imaging and intervention journal
影响因子：
--
作者：
Cheung, Ky
通讯作者：
Cheung, Ky
影响因子：
158.5
作者：
Lin, JC;Wang, WY;Jiang, RS
通讯作者：
Jiang, RS