The dysplastic nevus syndrome: our definition.
The dysplastic nevus syndrome: our definition.
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发育不良痣综合征：我们的定义。
DOI：
10.1097/00000372-198210000-00014
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
ClarkJr,WH
中科院分区：
文献类型：
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作者：
Elder,DE;Green,MH;Guerry4th,D;Kraemer,KH;ClarkJr,WH
恶性肿瘤如恶性黑色素瘤的诊断是一个“戏剧性的事件”，不仅对受影响的个人，而且对临床上怀疑病情的医生，由病理学家证实，并负责管理。在这种情况下，临床的注意力自然从病变事件的前因转移到对未来事件的考虑上，即肿瘤的治疗和“确定性”治疗后疾病的自然历史。在恶性黑色素瘤的情况下，一系列丰富的预后变量可用于帮助决定有关管理和评估预后。所有恶性黑色素瘤都不具有同样的危险性，这一点并不奇怪，但在过去的20年里，这一信息的发展缓慢。直到最近，人们才广泛接受这样一种观点，即一些黑色素瘤不太可能复发和转移，因此可以而且应该相应地修改其管理方法。"?人们通常认为（我们也同意这种假设），“高风险”黑色素瘤以某种方式出现在“低风险”病例中，这个病例库现在占美国大学44%的患者。
The diagnosis of a malignant neoplasm such as a malignant melanoma is a “dramatic event,” not only for affected individuals but also for physicians who suspect the condition clinically, have it confirmed by a pathologist, and are responsible for management. In this setting, clinical attention is naturally directed away from the antecedents of events of the lesion to consideration of future events, namely, thc management of the neoplasm and the natural his-tory of the disease following “definitive” therapy. In the case of a malignant melanoma, a rich array of prognostic variables is available to assist in deci-sions about management and in assessing prognosis. lt should come as no surprise to learn that all ma-lignant melanomas do not carry the same sinister significance, yet this information has evolved slowly in the last 20 years. Only very recently has there been wide acceptance of the idea that some mela-nomas are very unlikely to recur and metastasize, and that their management can and should be modificd accordingly."? It has commonly been assumed (and we share this assumption) that “high-risk” melanomas arise somehow out of this pool of “low-risk” cases, a pool that now comprises 44% of the patients in the Uni-