Diversity in protein domain superfamilies.
Diversity in protein domain superfamilies.
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DOI：
10.1016/j.gde.2015.09.005
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发表时间：
2015-12
影响因子：
4
通讯作者：
Orengo CA
中科院分区：
文献类型：
--
作者：
Das S;Dawson NL;Orengo CA
虽然根据来自∼-Gene3D域分类资源的可用数据，93%的域超家族在结构和功能上似乎是相对保守的，但其余的要多样化得多。在这篇综述中，我们考虑了一些最普遍和最混杂的超家族中的结构域是如何进化的，特别是它们功能部位和表面的可塑性，这扩大了它们相互作用的分子和对它们执行的操作的范围。我们能在多大程度上确定这些超家族的核心功能，从而使我们能够发展出一种“功能的域语法”，从而可以从蛋白质的构成域中提出蛋白质的生物学作用？显然，第一步是了解这些成分的差异程度，以及它们分子组成的变化如何改变功能。
Whilst ∼93% of domain superfamilies appear to be relatively structurally and functionally conserved based on the available data from the CATH-Gene3D domain classification resource, the remainder are much more diverse. In this review, we consider how domains in some of the most ubiquitous and promiscuous superfamilies have evolved, in particular the plasticity in their functional sites and surfaces which expands the repertoire of molecules they interact with and actions performed on them. To what extent can we identify a core function for these superfamilies which would allow us to develop a ‘domain grammar of function’ whereby a protein's biological role can be proposed from its constituent domains? Clearly the first step is to understand the extent to which these components vary and how changes in their molecular make-up modifies function.