Antagonism between the HIV-1 reverse-transcriptase mutation K65R and thymidine-analogue mutations at the genomic level.
Antagonism between the HIV-1 reverse-transcriptase mutation K65R and thymidine-analogue mutations at the genomic level.
复制标题
HIV-1 逆转录酶突变 K65R 和胸苷类似物突变在基因组水平上的拮抗作用。
DOI：
10.1086/505711
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Mellors,JohnW
中科院分区：
文献类型：
--
作者：
Parikh,UrviM;Barnas,DouglasC;Faruki,Hawazin;Mellors,JohnW
Prior virologic and biochemical studies have shown phenotypic antagonism between K65R and multiple thymidine-analogue mutations (TAMs) in site-directed mutants tested in vitro. We hypothesized, on the basis of this observed antagonism, that K65R and T215Y/F with multiple TAMs would not be selected on the same human immunodeficiency virus type 1 genome in vivo. We searched a large database of patient genotypes (n=59,262) for the frequency of K65R in combination with ⩾3 TAMs as determined by standard population sequencing. K65R and multiple TAMs were rarely detected (<0.1%) in the same plasma sample. Samples with both K65R and ⩾3 TAMs (n=21) were further analyzed by use of single-genome sequencing. K65R was never found on the same genome with T215F/Y and ⩾2 other TAMs, except in the presence of the Q151M multiple nucleoside reverse-transcriptase inhibitor (NRTI)–resistance complex. These results indicate that antagonism between the K65R and T215Y/F pathways of NRTI resistance occurs at the genomic level. Therapy with NRTI combinations that select both pathways simultaneously may delay the emergence of NRTI resistance and prolong treatment response
登录
查看更多内容
K65R 联合或不联合 S68：在大多数阿巴卡韦、地达诺辛和司他夫定治疗失败的患者中检测到新的体内耐药情况
影响因子：
1.2
作者：
B. Røge;T. Katzenstein;N. Obel;H. Nielsen;O. Kirk;C. Pedersen;L. Mathiesen;J. Lundgren;J. Gerstoft
通讯作者：
J. Gerstoft
一项试点研究中的早期病毒学失败，该研究评估了每日一次阿巴卡韦、拉米夫定和替诺福韦 DF 治疗对初治 HIV 感染患者的疗效。
DOI：
--
发表时间：
2005
期刊：
AIDS Patients Care and STDs
影响因子：
--
作者：
H. Khanlou;V. Yeh;Bill Guyer;C. Farthing
通讯作者：
C. Farthing
新核苷/核苷酸骨架选项的耐药性问题
DOI：
10.1097/01.qai.0000137005.63376.6e
发表时间：
2004
期刊：
JAIDS Journal of Acquired Immune Deficiency Syndromes
影响因子：
--
作者：
M. Wainberg;D. Turner
通讯作者：
D. Turner
影响因子：
6.4
作者：
Maeda, Y;Venzon, DJ;Mitsuya, H
通讯作者：
Mitsuya, H
同时使用齐多夫定对含阿巴卡韦方案选择的耐药途径的影响
影响因子：
3
作者：
E. R. Lanier;N. Givens;C. Stone;P. Griffin;D. Gibb;S. Walker;M. Tisdale;D. Irlbeck;M. Underwood;M. H. S. Clair;M. Ait‐Khaled
通讯作者：
M. Ait‐Khaled