P85gag-mos encoded by ts110 Moloney murine sarcoma virus: rapid at the restrictive temperature.
P85gag-mos encoded by ts110 Moloney murine sarcoma virus: rapid at the restrictive temperature.
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由 ts110 莫洛尼鼠肉瘤病毒编码的 P85gag-mos：在限制温度下快速。
DOI：
10.1099/0022-1317-64-10-2203
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Arlinghaus,RB
中科院分区：
文献类型：
--
作者：
Stanker,LH;Gallick,GE;Horn,JP;Arlinghaus,RB
本文研究了小鼠肉瘤病毒ts 110编码的P85 gag-mos的稳定性。在两种不同的细胞系中，发现P85 gag-mos在39 °C比33 °C更快地翻转。其中之一是非生产细胞克隆（6 m2），其似乎仅在33 °C下表达P85。另一种细胞系（206- 2 IC）在33 °C和39 °C下都产生P85 gag-mosat，尽管在较高温度下以较低的量。这两种细胞系表现出正常的形态表型转移到限制性温度。这些数据表明P85 gag-莫沙龙的存在不足以引起转化，并且与该分子相关的一些功能可能是热不稳定的。
The stability of P85gag-mos, encoded by ts110 Moloney murine sarcoma virus, was studied. P85gag-moswas found to turn over more rapidly at 39 °C than 33 °C in two different cell lines. One of these is a non-producer cell clone (6m2) which appears only to express P85 at 33 °C. The other cell line (206-2IC) produces P85gag-mosat both 33 °C and 39 °C, although in lower amounts at the higher temperature. Both cell lines exhibit the normal morphological phenotype following a shift to the restrictive temperature. These data suggest that the presence of P85gag-mosalone is insufficient to cause transformation, and that some function(s) associated with the molecule may be heat-labile.