Conflict of interest in clinical practice guideline development: a systematic review.
Conflict of interest in clinical practice guideline development: a systematic review.
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临床实践指南开发中的利益冲突：系统审查。
DOI：
10.1371/journal.pone.0025153
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Burda BU
中科院分区：
文献类型：
--
作者：
Norris SL;Holmer HK;Ogden LA;Burda BU
有一个新兴的文献的存在和影响的行业关系的医生和研究人员的行为。然而，关于这些关系和其他利益冲突（COI）对临床实践指南（CPG）制定和建议的影响，人们知之甚少。我们对COI的患病率及其对CPG建议的影响进行了系统回顾。我们在Medline（1980年至2011年3月）中搜索了检查COI对CPG发育和/或建议的影响的研究。数据综合是定性的。12项研究符合入选标准; 9项在美国进行。所有研究都报告了CPG作者与制药行业的财务关系;一项研究还检查了与诊断测试和保险公司的关系。大多数指南的作者都有行业背景，包括咨询公司（有关系的作者，范围6-80%）;研究支持（4-78%）;股权/股票所有权（2-17%）;或任何COI（56-87%）。4项研究报告了单个作者的多种类型的财务互动（每个作者的类型数量：范围2至10或更多）。关于COI对CPG建议的影响的数据仅限于案例研究，其中具有特定财务关系的作者似乎从相关的CPG建议中受益。在一项研究中，很少有作者认为他们的关系影响了他们的建议。没有研究报告CPG中的智力COI。有有限的数据描述了CPG作者中COI的高患病率，并且只有COI对CPG建议的影响的案例研究。需要进一步的研究来探索这种潜在的偏见来源。
There is an emerging literature on the existence and effect of industry relationships on physician and researcher behavior. Much less is known, however, about the effects of these relationships and other conflicts of interest (COI) on clinical practice guideline (CPG) development and recommendations. We performed a systematic review of the prevalence of COI and its effect on CPG recommendations. We searched Medline (1980 to March, 2011) for studies that examined the effect of COI on CPG development and/or recommendations. Data synthesis was qualitative. Twelve studies fulfilled inclusion criteria; 9 were conducted in the US. All studies reported on financial relationships of CPG authors with the pharmaceutical industry; 1 study also examined relationships with diagnostic testing and insurance companies. The majority of guidelines had authors with industry affiliations, including consultancies (authors with relationship, range 6–80%); research support (4–78%); equity/stock ownership (2–17%); or any COI (56–87%). Four studies reported multiple types of financial interactions for individual authors (number of types per author: range 2 to 10 or more). Data on the effect of COI on CPG recommendations were confined to case studies wherein authors with specific financial ties appeared to benefit from the related CPG recommendations. In a single study, few authors believed that their relationships influenced their recommendations. No studies reported on intellectual COI in CPGs. There are limited data describing the high prevalence of COI among CPG authors, and only case studies of the effect of COI on CPG recommendations. Further research is needed to explore this potential source of bias.
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影响因子：
158.5
作者：
Campbell, Eric G.;Gruen, Russell L.;Blumenthal, David
通讯作者：
Blumenthal, David
DOI：
10.1001/jama.1992.03490170092032
发表时间：
1992-11-04
影响因子：
120.7
作者：
GUYATT, G
通讯作者：
GUYATT, G
影响因子：
120.7
作者：
CHREN, MM;LANDEFELD, CS
通讯作者：
LANDEFELD, CS
影响因子：
--
作者：
Chaudhry, S;Schroter, S;Morris, J
通讯作者：
Morris, J
影响因子：
120.7
作者：
Choudhry, NK;Stelfox, HT;Detsky, AS
通讯作者：
Detsky, AS