Short-term exposure to air pollution and occurrence of emergency stroke in Chongqing, China
Short-term exposure to air pollution and occurrence of emergency stroke in Chongqing, China
复制标题
中国重庆市短期暴露于空气污染与紧急脑卒中的发生
DOI：
10.1007/s00420-020-01557-y
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发表时间：
2020-06-19
影响因子：
3
通讯作者：
Luo, Yongjun
中科院分区：
文献类型：
--
作者：
Tang, Caizhi;Chen, Yu;Luo, Yongjun
目的研究不同地区空气污染与卒中(尤其是急诊卒中)的关系，确定哪种空气污染物与卒中的相关性最显著。方法收集重庆市大型综合性医院2013年12月至2018年5月的急诊卒中患者数、空气污染物监测数据及相关气象指标。结果在对气象指标和周内效应进行分析和调整后，在单污染物模型中，臭氧浓度每增加10μg/m 3，急诊卒中的变化在滞后0内的变化率为2.482%(95%CI 1.044%，3.919%)。对于男性，臭氧每增加10μg/m~3，与女性相比，其贡献增加0.77个百分点。对于60岁以下的人群，我们观察到臭氧浓度每增加10μg/m~3，风险就增加1.14%。有高血压史的人群的风险比没有高血压史的人群高0.26%，臭氧浓度每增加10μg/m~3。在双污染物模型中，当臭氧浓度增加10μg/m~3时，发生急诊卒中的危险性增加0.22%。结论短期暴露在0天内的臭氧暴露与急诊卒中有关，年轻人群(年龄 <； 60岁)男性和高血压患者比老年人、女性和既往无高血压的人群更敏感。
ObjectiveThis study aimed to study the relationship between air pollution and stroke (especially emergency stroke) in different regions and determine which air pollutant is the most significantly associated with stroke.MethodsThe number of patients with emergency stroke, air pollutant data and related meteorological indicators were collected from December 2013 to May 2018 for large comprehensive hospitals in Chongqing. The generalized additive model was used to analyse the relationship between air pollution and emergency stroke.ResultsAfter analysis and adjusting for meteorological indicators and day-of-the-week effects, in the one-pollutant model, every 10 μg/m3increase in ozone(O3) was associated with a 2.482% (95% CI 1.044%, 3.919%) change in emergency strokes within lag0. For males, every 10 μg/m3increase of O3contributed to a 0.77% percent greater change compared with females. For the group younger than 60 years, we observed a 1.14% increase in risk with every 10 μg/m3increase in O3. The group with pre-existing hypertension had a 0.26% higher risk than the group with no pre-existing hypertension with every 10 μg/m3increase in O3. In two-pollutant model, when O3was combined with a 10 μg/m3increase of NO2, it increased the most significant risk of emergency stroke by 0.22%.ConclusionThese findings suggest that short-term exposure to O3within 0 days is associated with emergency outpatient strokes, and younger people (age < 60 years) males and people with hypertension are more sensitive than older people, females and people without pre-existing hypertension.