Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes
Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes
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DOI：
10.2337/diabetes.50.11.2497
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发表时间：
2001-11-01
期刊：
影响因子：
7.7
通讯作者：
Nauck, MA
中科院分区：
文献类型：
--
作者：
Meier, JJ;Hüking, K;Nauck, MA
在2型糖尿病患者中，胃抑制多肽（GIP）失去了大部分的促胰岛素活性。这种情况在2型糖尿病患者的一级亲属中是否相似尚不清楚。对21名一级亲属、10名2型糖尿病患者和10名口服糖耐量正常的对照组进行检查。在高血糖“钳夹”（140 mg/dl持续120分钟）期间，合成人GIP （2 pmol / kg(-1)）。静脉滴注Min (-1) （30-90 Min）。对于外源性GIP， 2型糖尿病患者的胰岛素增量（δ） （P = 0.0003）和c肽浓度（P < 0.0001）低于对照组。与对照组相比，一级亲属的GIP效应减弱（δ胰岛素：P = 0.04； δ c肽：P = 0.016），但显著高于2型糖尿病患者（P≤0.05）。在21名2型糖尿病患者的一级亲属中，7名（胰岛素）和11名（c肽）的反应在时间过程中低于对照受试者的95% CI。总之，在血糖正常的2型糖尿病患者的一级亲属中，GIP的促胰岛素活性降低是典型的，这可能是一种早期的遗传缺陷。
In patients with type 2 diabetes, gastric inhibitory polypeptide (GIP) has lost much of its insulinotropic activity. Whether this is similar in first-degree relatives of patients with type 2 diabetes is unknown. A total of 21 first-degree relatives, 10 patients with type 2 diabetes, and 10 control subjects (normal oral glucose tolerance) were examined. During a hyperglycemic "clamp" (140 mg/dl for 120 min), synthetic human GIP (2 pmol kg(-1) . min(-1)) was infused intravenously (30-90 min). With exogenous GIP, patients with type 2 diabetes responded with a lower increment (Delta) in insulin (P = 0.0003) and C-peptide concentrations (P < 0.0001) than control subjects. The GIP effects in first-degree relatives were diminished compared with control subjects (Delta insulin: P = 0.04; Delta C-peptide: P = 0.016) but significantly higher than in patients with type 2 diabetes (P less than or equal to 0.05). The responses over the time course were below the 95% CI derived from control subjects in 7 (insulin) and 11 (C-peptide) of 21 first-degree relatives of patients with type 2 diabetes. In conclusion, a reduced insulinotropic activity of GIP is typical for a substantial subgroup of normoglycemic first-degree relatives of patients with type 2 diabetes, pointing to an early, possibly genetic defect.